23210-22-2 Usage
Description
3-METHYL-1-PHENYLINDOLIN-2-ONE is an organic compound that serves as a key intermediate in the synthesis of various pharmaceuticals and chemical products. It is characterized by its unique molecular structure, which includes a methyl group and a phenyl group attached to an indolinone core. This structure endows it with specific chemical properties that make it valuable in a range of applications.
Uses
Used in Pharmaceutical Industry:
3-METHYL-1-PHENYLINDOLIN-2-ONE is used as a reactant for the stereoselective preparation of oxindole derivatives via asymmetrical Michael addition. This application is significant because oxindole derivatives are known to possess a wide range of biological activities, including anti-inflammatory, antimicrobial, and anticancer properties. The stereoselective synthesis of these derivatives allows for the production of specific isomers with desired biological activities, which can be further developed into effective drugs for various medical conditions.
Used in Chemical Synthesis:
In the field of chemical synthesis, 3-METHYL-1-PHENYLINDOLIN-2-ONE serves as a versatile building block for the creation of more complex molecules. Its unique structure allows for various chemical reactions, such as Michael addition, to be performed, leading to the formation of novel compounds with potential applications in different industries. This makes it a valuable tool for researchers and chemists working on the development of new materials and products.
Check Digit Verification of cas no
The CAS Registry Mumber 23210-22-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,3,2,1 and 0 respectively; the second part has 2 digits, 2 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 23210-22:
(7*2)+(6*3)+(5*2)+(4*1)+(3*0)+(2*2)+(1*2)=52
52 % 10 = 2
So 23210-22-2 is a valid CAS Registry Number.
InChI:InChI=1/C15H13NO/c1-11-13-9-5-6-10-14(13)16(15(11)17)12-7-3-2-4-8-12/h2-11H,1H3/t11-/m1/s1
23210-22-2Relevant articles and documents
Electrochemical Umpolung C-H Functionalization of Oxindoles
Pastor, Miryam,Vayer, Marie,Weinstabl, Harald,Maulide, Nuno
, p. 606 - 612 (2022/01/12)
Herein, we present a general electrochemical method to access unsymmetrical 3,3-disubstituted oxindoles by direct C-H functionalization where the oxindole fragment behaves as an electrophile. This Umpolung approach does not rely on stoichiometric oxidants and proceeds under mild, environmentally benign conditions. Importantly, it enables the functionalization of these scaffolds through C-O, and by extension to C-C or even C-N bond formation.
B(C6F5)3-Catalyzed Direct C3 Alkylation of Indoles and Oxindoles
Basak, Shyam,Alvarez-Montoya, Ana,Winfrey, Laura,Melen, Rebecca L.,Morrill, Louis C.,Pulis, Alexander P.
, p. 4835 - 4840 (2020/04/22)
The direct C3 alkylation of indoles and oxindoles is a challenging transformation, and only a few direct methods exist. Utilizing the underexplored ability of triaryl boranes to mediate the heterolytic cleavage of α-nitrogen C-H bonds in amines, we have developed a catalytic approach for the direct C3 alkylation of a wide range of indoles and oxindoles using amine-based alkylating agents. We also employed this borane-catalyzed strategy in an alkylation-ring opening cascade.
Iron-Catalyzed Methylation Using the Borrowing Hydrogen Approach
Polidano, Kurt,Allen, Benjamin D. W.,Williams, Jonathan M. J.,Morrill, Louis C.
, p. 6440 - 6445 (2018/07/25)
A general iron-catalyzed methylation has been developed using methanol as a C1 building block. This borrowing hydrogen approach employs a Kn?lker-type (cyclopentadienone)iron carbonyl complex as catalyst (2 mol %) and exhibits a broad reaction scope. A variety of ketones, indoles, oxindoles, amines, and sulfonamides undergo mono- or dimethylation in excellent isolated yields (>60 examples, 79% average yield).
