232279-44-6

Basic information

• Product Name: Trp-Aib-Gly-Leu-NHPh
• Synonyms: Trp-Aib-Gly-Leu-NHPh
• CAS NO: 232279-44-6
• Molecular Weight: 534.659
• Mol File: 232279-44-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Trp-Aib-Gly-Leu-NHPh(CAS DataBase Reference)
• NIST Chemistry Reference: Trp-Aib-Gly-Leu-NHPh(232279-44-6)
• EPA Substance Registry System: Trp-Aib-Gly-Leu-NHPh(232279-44-6)

Safety Data

• Hazardous Substances Data: 232279-44-6(Hazardous Substances Data)

Upstream product

• 271600-49-8 Z-Trp-Aib-Gly 
• 232279-49-1 Z-Trp-Aib-Gly-OMe 
• 84758-67-8 methyl N-(2-(((benzyloxy)carbonyl)amino)-2-methylpropanoyl)glycinate 
• 271770-09-3 Z-Trp-Aib-Gly-Leu-NHPh 

Relevant articles and documents

Recognition of quaternary ammonium salts with tetrapeptides containing α-aminoisobutyric acid as a conformational constraint

Tetrapeptides Trp-Aib-Gly-Leu-NH-Ar (Aib:α-aminoisobutyric acid, 2-amino-2-methylpropanoic acid, Ar = phenyl or 3,5-dimethylphenyl) were synthesized. The peptides bound quaternary ammonium salts as guests in CDCl3. For every guest, the binding constant K of the peptide host which has a 3,5-dimethylphenyl group was larger than that of the host which has a phenyl group. ROESY analysis of the complex revealed that the N+-CH3 groups of the guests were close to the aromatic moieties of the host in the complex. The charge in cation guests, the φ-basicity of the host, and the turn conformation of the peptides were important factors for the complexation.