23255-69-8

Basic information

• Product Name: FUSARENON X
• Synonyms: 12,13-epoxy-3alpha,4beta,7beta,15-tetrahydroxy-trichothec-9-en-8-on4-aceta;12,13-epoxy-3-alpha,4-beta,7-beta,15-tetrahydroxytrichothec-9-en-8-one4-acet;3,7,15-trihydroxy-4-acetoxy-8-oxo-12,13-epoxy-delta(sup9)-trichothecene;3,7,15-trihydroxyscirp-4-acetoxy-9-en-8-one;4-acetyloxy-12,13-epoxy-3,7,15-trihydroxy-(3-alpha,4-beta,7-beta)-trichothec;4-acetyloxy-12,13-epoxy-3,7,15-trihydroxy-(3-alpha,4-beta,7-beta)-trichothec-9;7-beta)--bet;-9-en-8-one
• CAS NO: 23255-69-8
• Molecular Formula: C17H22O8
• Molecular Weight: 354.35
• EINECS: 200-835-2
• Product Categories: Chiral Reagents;Intermediates & Fine Chemicals;Mutagenesis Research Chemicals;Pharmaceuticals;mycotoxin
• Mol File: 23255-69-8.mol
• Article Data: 0

Chemical Properties

• Melting Point: 91-92℃
• Boiling Point: 407.59°C (rough estimate)
• Flash Point: 2 °C
• Appearance: /
• Density: 1.2646 (rough estimate)
• Vapor Pressure: 2.51E-15mmHg at 25°C
• Refractive Index: 1.4430 (estimate)
• Storage Temp.: −20°C
• PKA: 11.70±0.70(Predicted)
• CAS DataBase Reference: FUSARENON X(CAS DataBase Reference)
• NIST Chemistry Reference: FUSARENON X(23255-69-8)
• EPA Substance Registry System: FUSARENON X(23255-69-8)

Safety Data

• Hazard Codes: F,Xn,T+
• Statements: 11-20/21/22-36-36/37/38-28
• Safety Statements: 26-36/37-45-36/37/39-22-16
• RIDADR: 3172
• WGK Germany: 3
• RTECS: YD0160000
• HazardClass: 6.1(a)
• PackingGroup: I
• Hazardous Substances Data: 23255-69-8(Hazardous Substances Data)

Usage

Description

Fusarenon X is a type B trichothecene mycotoxin, typically derived from Fusarium species, and is primarily found in contaminated cereals. It possesses immunosuppressive and carcinogenic properties, inhibiting protein synthesis and disrupting DNA synthesis in actively proliferating cells. This leads to various harmful effects such as immunosuppression, intestinal malabsorption, developmental toxicity, and genotoxicity. Infected plants can metabolize Fusarenon X into fusarenon X-glucoside.

Uses

Used in Agricultural Industry:
Fusarenon X is used as a subject of study for understanding its impact on crop contamination and developing strategies to mitigate its harmful effects on human and animal health. The application reason is to address the issue of mycotoxin contamination in cereals and improve food safety.
Used in Pharmaceutical Research:
Fusarenon X is used as a research compound for investigating its immunosuppressive and carcinogenic properties. The application reason is to better understand the mechanisms of its toxicity and potentially develop countermeasures or treatments for the negative effects caused by its presence in the food chain.
Used in Toxicology and Environmental Health:
Fusarenon X is used as a reference mycotoxin for toxicological studies and environmental health assessments. The application reason is to evaluate the risks associated with mycotoxin exposure and develop guidelines for safe exposure levels and regulatory measures to protect public health.

Safety Profile

Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. An experimental teratogen. Experimental reproductive effects. Questionable carcinogen with experimental tumorigenic data. Human mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes.

InChI:InChI=1/C17H22O8/c1-7-4-9-16(5-18,12(22)10(7)20)15(3)13(24-8(2)19)11(21)14(25-9)17(15)6-23-17/h4,9,11-14,18,21-22H,5-6H2,1-3H3/t9?,11-,12?,13-,14?,15-,16+,17+/m1/s1