23256-12-4

Basic information

• Product Name: 1-Methyl-9H-pyrido[3,4-b]indole-3-carboxamide
• Synonyms: 1-Methyl-9H-pyrido[3,4-b]indole-3-carboxamide;GPA-127
• CAS NO: 23256-12-4
• Molecular Formula: C13H11 N3 O
• Molecular Weight: 225.2459
• Mol File: 23256-12-4.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 505.4°Cat760mmHg
• Flash Point: 259.5°C
• Appearance: /
• Density: 1.371g/cm³
• Vapor Pressure: 2.43E-10mmHg at 25°C
• Refractive Index: 1.769
• CAS DataBase Reference: 1-Methyl-9H-pyrido[3,4-b]indole-3-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Methyl-9H-pyrido[3,4-b]indole-3-carboxamide(23256-12-4)
• EPA Substance Registry System: 1-Methyl-9H-pyrido[3,4-b]indole-3-carboxamide(23256-12-4)

Safety Data

• Hazardous Substances Data: 23256-12-4(Hazardous Substances Data)

Usage

InChI:InChI=1/C13H11N3O/c1-7-12-9(6-11(15-7)13(14)17)8-4-2-3-5-10(8)16-12/h2-6,16H,1H3,(H2,14,17)

Upstream product

• 16641-82-0 1-methyl-β-carboline-3-carboxylic acid methyl ester 
• 191279-38-6 (3S)-1-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid methyl ester 
• 22329-38-0 harman-3-carboxylic acid 

Relevant articles and documents

Discovery and preliminary mechanism of 1-carbamoyl β-carbolines as new antifungal candidates

Natural β-carboline alkaloids are ideal models for the discovery of pharmaceutically important entities. Various 1-substituted β-carbolines were synthesized from commercially inexpensive tryptophan and demonstrated significant in vitro antifungal activity against G. graminis. Significantly, compound 4m (EC50 = 0.45 μM) with carboxamide at 1-position displayed the best efficacy and nearly 20 folds enhancement in antifungal potential compared to Silthiopham (EC50 = 8.95 μM). Moreover, compounds 6, 7, and 4i exhibited excellent in vitro antifungal activities and in vivo protective and curative activities against B. cinerea and F. graminearum. Preliminary mechanism studies revealed that compound 4m caused reactive oxygen species accumulation, cell membrane destruction, and deregulation of histone acetylation. These findings indicated that 1-carbamoyl β-carboline can be selected as a promising model for the discovery of novel and broad-spectrum fungicide candidates.