232604-74-9

Basic information

• Product Name: 4-Oxo-8-phenylsulfanyl-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester
• CAS NO: 232604-74-9
• Molecular Weight: 325.388
• Mol File: 232604-74-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-Oxo-8-phenylsulfanyl-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Oxo-8-phenylsulfanyl-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester(232604-74-9)
• EPA Substance Registry System: 4-Oxo-8-phenylsulfanyl-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester(232604-74-9)

Safety Data

• Hazardous Substances Data: 232604-74-9(Hazardous Substances Data)

Upstream product

• 1134-94-7 2-phenylsulfanyl-aniline 
• 87-13-8 diethyl 2-ethoxymethylenemalonate 
• 4171-83-9 2-nitrophenyl phenyl sulfide 
• 88-73-3 2-Chloronitrobenzene 
• 108-98-5 thiophenol 

Relevant articles and documents

Synthesis and antitumor activity of some new substituted quinolin-4- one and 1,7-naphthyridin-4-one analogs

The synthesis of some new analogs of quinolin-4-one and 1,7- naphthyridin-4-one is described. The prepared compounds were tested for their in vitro antitumor and cdc2 kinase or cdc25 phosphatase inhibitory activity. Compound ethyl 7-oxo-2,3-dihydro-7H-pyrido [1,2,3-de][2,3- b]pyrido-1,4-thiazine-6-carboxylate (6b) showed antitumor activity against CNS SNB-75, breast T-47D, and lung NCI-H522 cancer cell lines with GI50 values of 8.3, 17.6, and 22.7 μM, respectively. Meanwhile, the compounds ethyl 4-oxo-8-phenylthio-1H,4H-quinoline-3-carboxylate (11a) and 4-oxo-8- phenylthio-1H,4H-1,7-naphthyridine-3-carboxylic acid (12b) have proved to be cdc25 phosphatase inhibitors at IC50 values of 11 and 5 μM, respectively.