23288-88-2

Basic information

• Product Name: 2-(methylthio)-5-phenyl-1,3,4-oxadiazole
• CAS NO: 23288-88-2
• Molecular Weight: 192.241
• Mol File: 23288-88-2.mol
• Article Data: 15

Chemical Properties

• CAS DataBase Reference: 2-(methylthio)-5-phenyl-1,3,4-oxadiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(methylthio)-5-phenyl-1,3,4-oxadiazole(23288-88-2)
• EPA Substance Registry System: 2-(methylthio)-5-phenyl-1,3,4-oxadiazole(23288-88-2)

Safety Data

• Hazardous Substances Data: 23288-88-2(Hazardous Substances Data)

Usage

General Description

2-(methylthio)-5-phenyl-1,3,4-oxadiazole is a chemical compound with the molecular formula C9H8N2OS and a molecular weight of 192.24 g/mol. It is a heterocyclic compound that contains both nitrogen and sulfur atoms in its structure. 2-(methylthio)-5-phenyl-1,3,4-oxadiazole has potential applications in the field of pharmaceuticals, as it exhibits anti-inflammatory, antimicrobial, and antifungal properties. It is also used in the synthesis of organic compounds and as a building block for other chemical reactions. Additionally, 2-(methylthio)-5-phenyl-1,3,4-oxadiazole has been studied for its potential use in the development of new materials for electronic and optical devices due to its unique structure and properties. However, it is important to handle this compound with care, as it may have potential health hazards if not used properly.

Upstream product

• 3004-42-0 5-phenyl-1,3,4-oxadiazole-2(3H)-thione 
• 77-78-1 dimethyl sulfate 
• 29515-99-9 5-methylsulfanyl-1H-tetrazole 
• 93-97-0 benzoic acid anhydride 
• 3004-42-0 2-Mercapto-5-phenyl-1,3,4-oxadiazole 
• 74-88-4 methyl iodide 
• 75-15-0 carbon disulfide 
• 613-94-5 benzoic acid hydrazide 
• 65-85-0 benzoic acid 
• 93-58-3 benzoic acid methyl ester 
• 825-56-9 2-phenyl-1,3,4-oxadiazole 
• 67-68-5 dimethyl sulfoxide 
• 5351-66-6 benzoyl thiosemicarbazide 
• 98-88-4 benzoyl chloride 

Downstream Products

• 4396-48-9 2-(N,N-dimethylamino)-5-phenyl-1,3,4-oxadiazole 
• 7111-93-5 3-methyl-5-phenyl-1,3,4-oxadiazoline-2-thione 
• 1321878-21-0 2-(dodecylthio)-5-phenyl-1,3,4-oxadiazole 
• 23766-21-4 2-Azido-5-phenyl-1,3,4-oxadiazol 
• 130161-41-0 3-(5-phenyl-1,3,4-oxadiazol-2-yl)-2,4-pentanedione 
• 861229-55-2 2-chloro-benzoic acid N'-(5-phenyl-[1,3,4]oxadiazol-2-yl)-hydrazide 
• 35220-12-3 2-Hydrazino-5-phenyl-1,3,4-oxadiazole 
• 23767-32-0 2-(methylsulfonyl)-5-phenyl-1,3,4-oxadiazole 

Relevant articles and documents

Nickel-Catalyzed Inter- and Intramolecular Aryl Thioether Metathesis by Reversible Arylation

A nickel-catalyzed aryl thioether metathesis has been developed to access high-value thioethers. 1,2-Bis(dicyclohexylphosphino)ethane (dcype) is essential to promote this highly functional-group-tolerant reaction. Furthermore, synthetically challenging macrocycles could be obtained in good yield in an unusual example of ring-closing metathesis that does not involve alkene bonds. In-depth organometallic studies support a reversible Ni0/NiII pathway to product formation. Overall, this work not only provides a more sustainable alternative to previous catalytic systems based on Pd, but also presents new applications and mechanistic information that are highly relevant to the further development and application of unusual single-bond metathesis reactions.

Chemical modification of lipase for rational enhancement of enantioselectivity

Chemical modifications of the I287C mutant of a Burkholderia cepacia lipase afforded various I287C-X conjugates, among which I287C-PAA bearing an N-phenylacetamide (PAA) moiety showed excellent enantioselectivity and catalytic activity for secondary alcohols. Site-directed chemical modifications are powerful tools to control enantioselective biocatalysis.

Synthesis, antibacterial activities, and 3d-qsar of sulfone derivatives containing 1, 3, 4-oxadiazole moiety

A series of sulfone derivatives containing 1, 3, 4-oxadiazole moiety were prepared and evaluated for their antibacterial activities by the turbidimeter test. Most compounds inhibited growth of Ralstonia solanacearum (R. solanacearum) from tomato and tobacco bacterial wilt with high potency, among which compounds 5a and 5b exhibited the most potent inhibition against R. solanacearum from tomato and tobacco bacterial wilts with EC50 values of 19.77 and 8.29 μg/mL, respectively. Our results also demonstrated that 5a, 5b, and a number of other compounds were more potent than commercial bactericides Kocide 3000 and Thiodiazole Copper, which inhibited R. solanacearum from tomato bacterial wilt with EC50 values of 93.59 and 99.80 μg/mL and tobacco bacterial wilt with EC50 values of 45.91 and 216.70 μg/mL, respectively. The structure-activity relationship (SAR) of compounds was studied using three-dimensional quantitative structure-activity relationship (3D-QSAR) models created by comparative molecular field analysis (CoMFA) and comparative molecular similarity index analysis (CoMSIA) based on compound bioactivities against tomato and tobacco bacterial wilts. The 3D-QSAR models effectively predicted the correlation between inhibitory activity and steric-electrostatic properties of compounds.