232951-83-6

Basic information

• Product Name: tert-Butyl 2-chloronicotinate
• Synonyms: tert-Butyl 2-chloronicotinate;2-Chloro-nicotinic acid tert-butyl ester;tert-Butyl 2-chloro-3-pyridinecarboxylate;tert-butyl 2-chloropyridine-3-carboxylate
• CAS NO: 232951-83-6
• Molecular Formula: C₁₀H₁₂ClNO₂
• Molecular Weight: 213.66078
• Mol File: 232951-83-6.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 275.6±20.0 °C(Predicted)
• Appearance: /
• Density: 1.173±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: -1.48±0.10(Predicted)
• CAS DataBase Reference: tert-Butyl 2-chloronicotinate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-Butyl 2-chloronicotinate(232951-83-6)
• EPA Substance Registry System: tert-Butyl 2-chloronicotinate(232951-83-6)

Safety Data

• Hazardous Substances Data: 232951-83-6(Hazardous Substances Data)

Usage

General Description

Tert-Butyl 2-chloronicotinate, also known as TBNC, is a chemical compound that belongs to the class of nicotinate esters. It is primarily used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. TBNC is a white crystalline solid with a molecular weight of 209.67 g/mol and a melting point of 105-107°C. It is soluble in organic solvents such as methanol, ethanol, acetone, and chloroform. TBNC is known for its potential applications in the field of medicinal chemistry, particularly in the development of drugs for the treatment of various diseases. It is also used in the production of insecticides and herbicides due to its effective pesticidal properties. Additionally, it is widely utilized in the research and development of new chemical entities in the pharmaceutical and agricultural industries.

Upstream product

• 2942-59-8 2-chloronicotinic acid 
• 865-47-4 potassium tert-butylate 
• 464216-16-8 tert-butyl 2-aminopyridine-3-carboxylate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 75-65-0 tert-butyl alcohol 
• 121495-79-2 2-chloropyridine-3-carbonyl chloride hydrochloride 
• 49609-84-9 2-Chloronicotinoyl chloride 

Downstream Products

• 464216-16-8 tert-butyl 2-aminopyridine-3-carboxylate 
• 52682-09-4 (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 3-nitrobenzoate 
• 37787-77-2 Boc-L-proline benzyl ester 

Relevant articles and documents

A biotin-conjugated pyridine-based isatoic anhydride, a selective room temperature RNA-acylating agent for the nucleic acid separation

Isatoic anhydride derivatives, including a biotin and a disulfide linker were specifically designed for nucleic acid separation. 2′-OH selective RNA acylation, capture of biotinylated RNA adducts by streptavidin-coated magnetic beads and disulfide chemica

Methods of functionalization and reagents used in such methods using an aza-isatoic anhydride or a derivative thereof, biological molecules thus treated and kits

The present invention relates to a method of functionalization of at least one ribonucleic acid (RNA) molecule, contained in a liquid sample, which includes the following steps: a) providing at least: one binding molecule consisting of an aza-isatoic anhydride or a derivative thereof, one group of interest, and one linkage joining the binding molecule to the group of interest, b) reacting the anhydride function of the binding molecule with at least one hydroxyl group carried: in position 2′ of the ribose of one of the RNA nucleotides, and/or in position(s) 2′ and/or 3′ of the ribose of the nucleotide at the terminal 3′ end of the RNA, and obtaining an aza-anthranilate that joins, by means of the linkage, the RNA to the group of interest.

METHOD FOR PRODUCING HETEROCYCLIC COMPOUND

The present invention provides a production method of heterocyclic compound having an excellent CH24H inhibitory action, which is suitable for industrial production. In the present invention, a 2-halogenonicotinic acid or a reactive derivative thereof or a salt thereof is reacted with 4-benzyl-4-hydroxypiperidine acid addition salt to give a (4-benzyl-4-hydroxypiperidin-1-yl) (2-halogenopyridin-3-yl)methanone or a salt thereof, and then the obtained compound is reacted with pyridine-4-boronic acid or a reactive derivative thereof or a salt thereof in the presence of a metal catalyst and a base to give (4-benzyl-4-hydroxypiperidin-1-yl) (2,4′-bipyridin-3-yl)methanone or a salt thereof.