23301-00-0Relevant articles and documents
Unorthodox cascade reaction of arynes and: N -nitrosamides leading to indazole scaffolds
Baidya, Mahiuddin,Bhajammanavar, Vinod,Choutipalli, Venkata Surya Kumar,Subramanian, Venkatesan,Sureshbabu, Popuri
supporting information, p. 1187 - 1190 (2022/02/03)
An unusual cascade annulation of arynes with N-alkyl-N-nitrosamides is developed by leveraging aryne σ-insertion and C(sp3)-H bond functionalization strategies under transition-metal-free conditions at ambient temperature, offering functionalized indazoles in high yields and regioselectivity. The protocol is scalable and exhibits a broad substrate scope. The reaction mechanism is also studied with DFT calculations.
