233266-52-9

Basic information

• Product Name: N^α-9-fluorenylmethoxycarbonyl-S-trityl-cysteine phenacyl ester
• Synonyms: N^α-9-fluorenylmethoxycarbonyl-S-trityl-cysteine phenacyl ester
• CAS NO: 233266-52-9
• Molecular Weight: 703.858
• Mol File: 233266-52-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N^α-9-fluorenylmethoxycarbonyl-S-trityl-cysteine phenacyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: N^α-9-fluorenylmethoxycarbonyl-S-trityl-cysteine phenacyl ester(233266-52-9)
• EPA Substance Registry System: N^α-9-fluorenylmethoxycarbonyl-S-trityl-cysteine phenacyl ester(233266-52-9)

Safety Data

• Hazardous Substances Data: 233266-52-9(Hazardous Substances Data)

Upstream product

• 103213-32-7 N-(9-fluorenylmethoxycarbonyl)-S-trityl-L-cysteine 
• 70-11-1 α-bromoacetophenone 

Downstream Products

• 233266-64-3 Fmoc-Cys(Fnam)-Phe-OMe 
• 233266-62-1 N^α-9-fluorenylmethoxycarbonyl-S-[N-[2,3,5,6-tetrafluoro-4-(N'-piperidino)phenyl]-N-(allyloxycarbonyl)aminomethyl]cysteine phenacyl ester 
• 233266-63-2 N^α-9-fluorenylmethoxycarbonyl-S-[N-[2,3,5,6-tetrafluoro-4-(N'-piperidino)phenyl]-N-(allyloxycarbonyl)aminomethyl]cysteine 
• 233266-53-0 N^α-9-fluorenylmethoxycarbonyl-cysteine phenacyl ester 

Relevant articles and documents

Allylic protection of thiols and cysteine: II: The N-[2,3,5,6- tetrafluoro-4-(N'-piperidino)-phenyl], N-allyloxycarbonylaminomethyl (Fnam) group

S-[N-[2,3,5,6-tetrafluoro-4-(N'-piperidino)-phenyl], N- allyloxycarbonyl]-aminomethyl (Fnam) derivatives of thiols in general and cysteine in particular are readily deprotected by palladium catalysed allylic cleavage in the presence of various nucleophilic species. They are perfectly stable in both the basic conditions (piperidine/DMF) of Fmoc group removal and the acidic conditions (TFA/CH2Cl2) of t-Bu and Boc group removal.