23428-81-1

Basic information

• Product Name: tert-butyl 4-(benzyloxy)-3-MethoxyphenethylcarbaMate
• Synonyms: tert-butyl 4-(benzyloxy)-3-MethoxyphenethylcarbaMate
• CAS NO: 23428-81-1
• Molecular Formula: C₂₁H₂₇NO₄
• Molecular Weight: 357.44338
• Mol File: 23428-81-1.mol
• Article Data: 3

Chemical Properties

• Melting Point: 68-70 °C
• Boiling Point: 498.9±40.0 °C(Predicted)
• Appearance: /
• Density: 1.096±0.06 g/cm3(Predicted)
• PKA: 12.60±0.46(Predicted)
• CAS DataBase Reference: tert-butyl 4-(benzyloxy)-3-MethoxyphenethylcarbaMate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 4-(benzyloxy)-3-MethoxyphenethylcarbaMate(23428-81-1)
• EPA Substance Registry System: tert-butyl 4-(benzyloxy)-3-MethoxyphenethylcarbaMate(23428-81-1)

Safety Data

• Hazardous Substances Data: 23428-81-1(Hazardous Substances Data)

Upstream product

• 554-52-9 3-Methoxytyramine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 23699-77-6 tert-butyl 4-hydroxy-3-methoxyphenethylcarbamate 
• 100-39-0 benzyl bromide 

Downstream Products

• 22231-61-4 2-[4-(benzyloxy)-3-methoxyphenyl]ethylamine 
• 1860-57-7 [2-(4-benzyloxy-3-methoxyphenyl)ethyl]amine hydrochloride 
• 1032821-81-0 N-[2-(4-benzyloxy-3-methoxyphenyl)ethyl]propionamide 
• 19886-92-1 1-ethyl-7-hydroxy-6-methoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride 

Relevant articles and documents

1,2,3,4-TETRAHYDROISOQUINOLINE DERIVATIVES HAVING EFFECTS OF PREVENTING AND TREATING DEGENERATIVE AND INFLAMMATORY DISEASES

Provided are 7-hydroxy-6-methoxy-1,2,3,4-tetrahydroisoquinoline derivatives and synthesis methods thereof. The compounds significantly inhibit the production of nitrogen monoxide (NO) and superoxide in an activated microglial cell and expressions of TNF-α, IL-1β inducive NO synthase and cyclooxygenase-2 genes. They also prevent NF-kB shift to a nucleus, decrease reactive oxygen species (ROS), inhibit expression of GTP cyclohydrolase I gene and over-production of tetrahydrobiopterin (BH4), and protect dopaminergic neurons from injury due to activated microglial cells. Consequently, the compounds are effective in treating inflammatory and neurodegenerative diseases.

Syntheses of tetrahydroisoquinoline derivatives that inhibit NO production in activated BV-2 microglial cells

Seventeen tetrahydroisoquinoline derivatives were designed, synthesized and evaluated for inhibition of NO production in lipopolysaccharide-stimulated BV-2 microglial cells. Compounds 5a, 9c and 11a potently attenuated NO production by >60%, and 5a and 11