23458-22-2

Basic information

• Product Name: Z-(S)-Ala-(S)-Pro-OBzl
• Synonyms: Z-(S)-Ala-(S)-Pro-OBzl
• CAS NO: 23458-22-2
• Molecular Weight: 410.47
• Mol File: 23458-22-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Z-(S)-Ala-(S)-Pro-OBzl(CAS DataBase Reference)
• NIST Chemistry Reference: Z-(S)-Ala-(S)-Pro-OBzl(23458-22-2)
• EPA Substance Registry System: Z-(S)-Ala-(S)-Pro-OBzl(23458-22-2)

Safety Data

• Hazardous Substances Data: 23458-22-2(Hazardous Substances Data)

Upstream product

• 5513-39-3 N-benzyloxycarbonyl-alanine benzyl ester 
• 16652-71-4 benzyl (2S)-2-pyrrolidinecarboxylate hydrochloride 
• 1142-20-7 N-Cbz-Ala 
• 28819-05-8 (S)-2-benzyloxycarbonylamino-propionic acid methyl ester 
• 41324-66-7 H-Pro-OBzl 
• 88718-12-1 Z-L-Ala benzyl ester 
• 130446-89-8 Z-L-Ala 2-chloroethyl ester 
• 49760-60-3 N-benzyloxycarbonyl-L-alanyl chloride 

Downstream Products

• 3918-95-4 alanylproline 

Relevant articles and documents

Incorporation of unnatural amino acid derivatives into a peptide bond via an oxime ester catalysed by papain or lipase

In the presence of an oxime in the reaction solution, papain and lipase P (Pseudomonas from Amano) catalysed the stereoselective transesterification of an N-protected amino acid or peptide ester to form an active (oxime) ester which in turn underwent peptide bond formation with several natural and unnatural amino acid derivatives (proline, N-methylglycine, N-methylalanine, α-methylphenylalanine).

Amino Acids and Peptides; 67. Easy Preparation and Use of Benzyloxycarbonyl Derivatives of Amino Acid Chlorides and α-Hydroxycarboxylic Acid Chlorides

N-Benzyloxycarbonyl amino acid chlorides and α-benzyloxycarbonyloxy carboxylic acid chlorides are readily available by treating the corresponding carboxylic acids with 1-chloro-N,N,2-trimethyl-1-propen-1-amine.They can be immediately reacted with O-, N- and C-nucleophiles to afford peptides, ketones and esters.