23496-62-0

Basic information

• Product Name: 4-chloro-2-(4,5-dihydrooxazol-2-yl)aniline
• Synonyms: 4-chloro-2-(4,5-dihydrooxazol-2-yl)aniline
• CAS NO: 23496-62-0
• Molecular Weight: 196.636
• Mol File: 23496-62-0.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 4-chloro-2-(4,5-dihydrooxazol-2-yl)aniline(CAS DataBase Reference)
• NIST Chemistry Reference: 4-chloro-2-(4,5-dihydrooxazol-2-yl)aniline(23496-62-0)
• EPA Substance Registry System: 4-chloro-2-(4,5-dihydrooxazol-2-yl)aniline(23496-62-0)

Safety Data

• Hazardous Substances Data: 23496-62-0(Hazardous Substances Data)

Upstream product

• 5922-60-1 2-amino-5-chlorobenzonitrile 
• 141-43-5 ethanolamine 

Relevant articles and documents

Nickel-Catalyzed Regioselective C–H Bond Mono- and Bis-Nitration of Aryloxazolines with tert-Butyl Nitrite as Nitro Source

An efficient and regioselective nickel-catalyzed remote C–H nitration of 2-aryloxazoline amides using the non-corrosive tert-butyl nitrite (TBN) as nitro source has been developed. The protocol makes use of inexpensive nickel salts as catalysts and delivers the corresponding products in excellent yields. Notably, bis-nitration products were obtained by simply increasing the amount of tert-butyl nitrite. This reaction proceeds in air and features excellent functional group compatibility, broad substrate scope and is suitable for gram-scale synthesis. (Figure presented.).

Base-promoted Lewis acid catalyzed synthesis of quinazoline derivatives

A one-pot protocol has been developed for the synthesis of quinazolinones from amide-oxazolines with TsCl via a cyclic 1,3-azaoxonium intermediate and 6π electron cyclization in the presence of a Lewis acid and base. The process is operationally simple and has a broad substrate scope. This method provides a unique strategy for the construction of quinazolinones.

Highly efficient synthesis of β-nitrate ester carboxamides through the ring-opening of 2-oxazolines

A novel method for the synthesis of β-nitrate ester carboxamides using non-corrosive tert-butyl nitrite (TBN) as the nitro source and easily available oxygen as the oxidant has been developed. Variously substituted 2-oxazolines were efficiently ring-opened to deliver the corresponding products in excellent yields. Notably, this reaction provides fast access to pharmaceuticals such as nicorandil.