23526-52-5

Basic information

• Product Name: methyl 12-methoxypodocarpa-6,8,11,13-tetraen-15-oate
• CAS NO: 23526-52-5
• Molecular Formula: C₁₉H₂₄O₃
• Molecular Weight: 300.3921
• Mol File: 23526-52-5.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 392.1°C at 760 mmHg
• Flash Point: 165.4°C
• Density: 1.087g/cm³
• Vapor Pressure: 2.35E-06mmHg at 25°C
• Refractive Index: 1.534
• CAS DataBase Reference: methyl 12-methoxypodocarpa-6,8,11,13-tetraen-15-oate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 12-methoxypodocarpa-6,8,11,13-tetraen-15-oate(23526-52-5)
• EPA Substance Registry System: methyl 12-methoxypodocarpa-6,8,11,13-tetraen-15-oate(23526-52-5)

Safety Data

• Hazardous Substances Data: 23526-52-5(Hazardous Substances Data)

Upstream product

• 23526-53-6 methyl 7β-hydroxy-12-methoxypodocarpa-8,11,13-trien-19-oate 
• 108-24-7 acetic anhydride 
• 1231-74-9 methyl O-methylpodocarpate 
• 901-36-0 methyl 12-methoxy-7-oxopodocarpa-8,11,13-trien-19-oate 
• 199291-62-8 methyl O-methyl-7-hydroxypodocarpate 
• 13057-17-5 bromethyl methyl ether 

Downstream Products

• 137986-96-0 methyl 7β-(3'-chlorobenzoyloxy)-6α-hydroxy-12-methoxypodocarpa-8,11,13-trien-19-oate 
• 137987-07-6 methyl 7α-(3'-chlorobenzoyloxy)-6α-hydroxy-12-methoxypodocarpa-8,11,13-trien-19-oate 
• 35318-99-1 methyl 6α,7β-dihydroxy-12-methoxypodocarpa-8,11,13-trien-19-oate 
• 137987-08-7 methyl 6α-(3'-chlorobenzoyloxy)-7α-hydroxy-12-methoxypodocarpa-8,11,13-trien-19-oate 
• 138125-88-9 methyl 6α,7α-dihydroxy-12-methoxypodocarpa-8,11,13-trien-19-oate 

Relevant articles and documents

Stereoselective synthesis and some reactions of β-(η6-arene)Cr(CO)3 complexes of podocarpic acid derivatives

The stereoselective synthesis of a number of (η6-arene)tricarbonylchrorniurn(0) complexes derived from podocarpic acid has been achieved in good to excellent yield. The stereochemistry of complexes 36 and 37 was established by X-ray crystallography. Reactions of some of the deprotonated complexes with electrophiles were investigated.

Investigation of the antitumor activity of podocarpic acid derivatives

As a class, octahydrophenanthrene lactones, podolactones, and related podocarpic acid derivatives have been reported to possess a wide variety of biological activities, including antileukemic activity, inhibition of plant cell growth, and hormonal and anti-inflammatory properties. In the present study, a series of synthetic intermediates derived from podocarpic acid have been prepared and evaluated with the respect to their ability to inhibit human epidermoid carcinoma of the nasopharynx in vitro. The significant cytotoxicity demonstrated by methyl 6α-bromo-7-oxo-O-methylpodocarpate (50% inhibition at 8.85 x 10-9 M) was markedly higher than that of the other derivatives examined. Further evaluation against L210 and P388 lymphoid leukemias in mice failed to demonstrate significant antitumor activity.