235426-30-9

Basic information

• Product Name: 2-BROMO-1,4-DIMETHYL-1H-IMIDAZOLE
• Synonyms: 2-BROMO-1,4-DIMETHYL-1H-IMIDAZOLE;1H-IMidazole,2-broMo-1,4-diMethyl;2-Bromo-1,4-dimethyl-1H-imidazole 98%;2-Bromo-1,4-dimethyl-1H-imidazole98%;2-bromo-1,4-dimethylimidazole
• CAS NO: 235426-30-9
• Molecular Formula: C₅H₇BrN₂
• Molecular Weight: 175.03
• Product Categories: blocks;Bromides;Imidazoles
• Mol File: 235426-30-9.mol
• Article Data: 1

Chemical Properties

• Melting Point: 46-50
• Boiling Point: 253.6 °C at 760 mmHg
• Flash Point: 107.1 °C
• Appearance: /
• Density: 1.58 g/cm³
• Vapor Pressure: 0.0181mmHg at 25°C
• Refractive Index: 1.589
• Storage Temp.: Keep Cold
• PKA: 4.28±0.60(Predicted)
• CAS DataBase Reference: 2-BROMO-1,4-DIMETHYL-1H-IMIDAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BROMO-1,4-DIMETHYL-1H-IMIDAZOLE(235426-30-9)
• EPA Substance Registry System: 2-BROMO-1,4-DIMETHYL-1H-IMIDAZOLE(235426-30-9)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22
• Hazardous Substances Data: 235426-30-9(Hazardous Substances Data)

Usage

General Description

2-Bromo-1,4-dimethyl-1H-imidazole is a chemical compound often used in scientific research, particularly in the field of chemistry. 2-BROMO-1,4-DIMETHYL-1H-IMIDAZOLE has the molecular formula C5H7BrN2 and is characterized by its aromatic heterocyclic organic compound structure, with an imidazole ring, two methyl groups, and one bromine atom attached. This specific compound is light-sensitive and needs to be stored in a dark, cool location when not in use. It can be synthesized through various methods, frequently involving bromination of the corresponding dimethyl-imidazole. Its applications vary, from being an intermediate in pharmaceutical research to the synthesis of more complex compounds in organic chemistry.

InChI:InChI=1/C5H7BrN2/c1-4-3-8(2)5(6)7-4/h3H,1-2H3

Upstream product

• 6338-45-0 1,4-dimethylimidazole 
• 60-29-7 diethyl ether 
• 506-68-3 bromocyane 

Downstream Products

• 1201641-37-3 N-cyclohexyl-N-(2,2-dimethoxyethyl)-3-(3-(1,4-dimethyl-1H-imidazol-2-yl)phenethoxy)propanamide 

Relevant articles and documents

Reaction of imidazoles with cyanogen bromide: Cyanation at N 1 or bromination at C 2?

The reaction in acetonitrile solution of a number of imidazoles (1H-, 1-methyl-, 2-methyl-, 4-methyl-, 1,2-, 1,4- and 1,5-dimethyl-, 1-ethyl-, 1-benzyl- and 1-butyl-imidazole) and imidazole complexes ([Co(NH3)5(imH)](ClO4)3, [Co(NH3)5(im)] (ClO4)2 and [Co(NH3)5(1-Meim)] (ClO4)3) with BrCN has been studied. Those imidazoles bearing an N-alkyl substituent and having a hydrogen at C2 react to give the 2-bromo products, while the N-H imidazoles react to give W-cyano derivatives. The product(s) from the reaction of 1,2-dimethylimidazole with BrCN could not be characterized. Of the complexes, only [Co(NH3)5(im)] (ClO4)2 reacts, giving the 2-bromo product. Our observations suggest a lone pair on a ring nitrogen atom is necessary for an imidazole to react with BrCN, and a possible mechanism is suggested. The X-ray structure of 2-methylimidazole-1-carbonitrile is reported. Crystal data (-143°C) for C5H5N3: monoclinic, P21/c, a 10.201(5), b 7.110(3), c 7.227(3) A, β 100.47(2)°, V 515.4(4) A3, Z 4, dcalcd 1-380 g cm-3. Refinement of the structure converged with R1 0.0444 for 1183 reflections with Fo > 4F(Fo) and ωR2 0.1259 for all 1278 data.