2356-36-7

Basic information

• Product Name: N-(3,5-bis(trifluoromethyl)phenyl)formamide
• Synonyms: N-(3,5-bis(trifluoromethyl)phenyl)formamide
• CAS NO: 2356-36-7
• Molecular Weight: 257.135
• Mol File: 2356-36-7.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: N-(3,5-bis(trifluoromethyl)phenyl)formamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3,5-bis(trifluoromethyl)phenyl)formamide(2356-36-7)
• EPA Substance Registry System: N-(3,5-bis(trifluoromethyl)phenyl)formamide(2356-36-7)

Safety Data

• Hazardous Substances Data: 2356-36-7(Hazardous Substances Data)

Upstream product

• 68-12-2 N,N-dimethyl-formamide 
• 328-74-5 3,5-Bis-(trifluoromethyl)aniline 
• 107-31-3 Methyl formate 
• 64-18-6 formic acid 

Downstream Products

• 74702-23-1 C₆H₃(CF₃)2N(CHO)SCFCl₂ 

Relevant articles and documents

Microwave-Assisted Formylations of Weakly Basic Anilines with Methyl Formate Catalyzed by Calcium and Hydrogen Triflimides

Catalytic amounts of calcium and hydrogen triflimides [Ca(NTf2)2, HNTf2] were found to be efficient for the solvent-free formylation of a variety of weakly basic anilines by using cheap and widely available methyl formate as the formylating agent under microwave irradiation. Initial investigations showed that in the case of calcium triflimide, Br?nsted acid catalysis was most likely operating. Remarkably, the corresponding calcium triflate and triflic acid were significantly less active.

KOtBu-Promoted Transition-Metal-Free Transamidation of Primary and Tertiary Amides with Amines

This work discloses transamidation of primary and tertiary amides with a range of aryl, heteroaryl, and aliphatic amines using potassium tert-butoxide. The reaction proceeds at room temperature under transition-metal-free conditions providing secondary amides in high yields. Moreover, reaction of cyclopropyl amine with tertiary amides proceeds with ring-opening to provide a rapid access to enamides.

FORMYLATION PROCESS FOR PREPARING AROMATIC FORMAMIDES

The present invention mainly pertains to a catalytic process for preparing a formamide,comprising reacting a formic acid ester with an aromatic amine carrying at least one electron withdrawing group in the presence of a catalyst of fluorine-containing sulfonimide metal salt.