2358-91-0Relevant articles and documents
Dimethylamination of Primary Alcohols Using a Homogeneous Iridium Catalyst: A Synthetic Method for N, N-Dimethylamine Derivatives
Jeong, Jaeyoung,Fujita, Ken-Ichi
, p. 4053 - 4060 (2021)
A new catalytic system for N,N-dimethylamination of primary alcohols using aqueous dimethylamine in the absence of additional organic solvents has been developed. The reaction proceeds via borrowing hydrogen processes, which are atom-efficient and environmentally benign. An iridium catalyst bearing an N-heterocyclic carbene (NHC) ligand exhibited high performance, without showing any deactivation under aqueous conditions. In addition, valuable N,N-dimethylamine derivatives, including biologically active and pharmaceutical molecules, were synthesized. The practical application of this methodology was demonstrated by a gram-scale reaction.
Compounds
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, (2008/06/13)
Polystyrene polymers of structure : in which, R1 and R2 are the same or different and are each C1 4 alkyl; R3 is (CH2)nR4 in which R4 is C3 6 cycloalkyl or a bicyclic carbocyclic ring of up to 10 carbon atoms and n is 1 to 12, or R3 is (CH2)nCH = R5R6 in which n is 1 to 12 and R5 and R6 together form a C3 6 cycloalkyl ring or a bicyclic carbocyclic ring of up to 10 carbon atoms; R7 is hydrogen or a group CH2N R1R2R3X ; X is a counter ion; a, b and c are numbers which indicate the relative molar percentages of the units present in said polymer, (b) being from about 1 to about 10 molar percent, and (c) being from about 30 to about 98 molar percent; m is a number indicating the degree of polymerisation of said polymer, processes for their preparation, compositions containing them and their use in therapy as bile acid sequestering agents.
