23585-97-9

Basic information

• Product Name: (4-bromo-phenyl)-(5-phenyl-[1,3,4]oxadiazol-2-yl)-amine
• CAS NO: 23585-97-9
• Molecular Weight: 316.157
• Mol File: 23585-97-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (4-bromo-phenyl)-(5-phenyl-[1,3,4]oxadiazol-2-yl)-amine(CAS DataBase Reference)
• NIST Chemistry Reference: (4-bromo-phenyl)-(5-phenyl-[1,3,4]oxadiazol-2-yl)-amine(23585-97-9)
• EPA Substance Registry System: (4-bromo-phenyl)-(5-phenyl-[1,3,4]oxadiazol-2-yl)-amine(23585-97-9)

Safety Data

• Hazardous Substances Data: 23585-97-9(Hazardous Substances Data)

Upstream product

• 65-85-0 benzoic acid 
• 2646-31-3 4-(p-bromophenyl)thiosemicarbazide 
• 1152-32-5 1-benzoyl-4-phenylsemicarbazide 
• 1148-89-6 2-phenylamino-5-phenyl-1,3,4-oxadiazole 

Downstream Products

• 32380-24-8 N-(4-bromo-phenyl)-N-(5-phenyl-[1,3,4]oxadiazol-2-yl)-acetamide 

Relevant articles and documents

Efficient one-pot synthesis of substituted 2-amino-1,3,4-oxadiazoles

A convenient one-pot method for the preparation of substituted 2-amino-1,3,4-oxadiazoles has been developed. The method is a significant improvement over previously reported syntheses. Reaction of carboxylic acids with thiosemicarbazides afforded the corresponding oxadiazoles in moderate to good yields. In general, the products precipitated from the reaction mixture, and were collected by filtration. In most of the cases, no chromatographic separations were required. To explore the scope and limitations of this reaction, various aliphatic, aromatic, and heteroaromatic carboxylic acids were reacted with different substituted thiosemicarbazides. The influence of R1 and R2 substituents on the reaction yield and additional results demonstrating the versatility of this method are presented.