23602-78-0 Usage
Originator
Mediator,Servier,France,1976
Uses
antihyperlipoproteinemic
Manufacturing Process
To a solution of 24.7 parts of 1-(m-trifluoromethylphenyl)-2-(β-
hydroxyethyl)amino propane in 140 parts of anhydrous benzene, there were
added successively 15 parts of 4.7N hydrochloric ether and a solution of 14
parts of benzoyl chloride in 24 parts of anhydrous benzene. The addition
required 10 minutes, the reaction mixture was then refluxed for 8 hours.
The solid product was collected by filtration and after recrystallization from
230 parts of ethyl acetate, there were obtained 15 parts of 1-(mtrifluoromethylphenyl)-
2-(β-benzoyloxyethyl)amino propane hydrochloride
melting at 161°C.
10 parts hydrochloride are put in suspension in 100 parts of water, 80 parts
ether are added, then 10 parts of a concentrated solution of ammonium
hydroxide. The mixture is stirred a few minutes until the salt is dissolved,
then the ethered solution is poured off and dried. After the ether is
eliminated, 9 parts of 1-(m-trifluoromethylphenyl)-2-(β-
benzoyloxyethyl)amino propane are obtained; the base is a colorless oil.
Therapeutic Function
Antihyperlipidemic, Cardiovascular
Check Digit Verification of cas no
The CAS Registry Mumber 23602-78-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,3,6,0 and 2 respectively; the second part has 2 digits, 7 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 23602-78:
(7*2)+(6*3)+(5*6)+(4*0)+(3*2)+(2*7)+(1*8)=90
90 % 10 = 0
So 23602-78-0 is a valid CAS Registry Number.
InChI:InChI=1/C19H20F3NO2/c1-14(12-15-6-5-9-17(13-15)19(20,21)22)23-10-11-25-18(24)16-7-3-2-4-8-16/h2-9,13-14,23H,10-12H2,1H3
23602-78-0Relevant articles and documents
A process for the preparation of 1-(3-trifluoromethylphenyl)-2-(2-benzoyloxyethylamino)-propane
-
, (2008/06/13)
A process for the preparation of 1-(3-trifluoromethylphenyl)-2-(-2-benzoyloxyethylamino)propane, in particular the highly pure crystalline hydrochloride, starting from 2-benzoylethanolamine hydrochloride and m-trifluoromethylphenylacetone.
