23651-95-8 Usage
Description
Droxidopa, also known as L-threo-3,4-Dihydroxyphenylserine or L-DOPS, is a synthetic amino acid precursor of norepinephrine (N674500) and a catecholamine. It is a prodrug for noradrenalone and has the ability to cross the blood-brain barrier. Droxidopa is transformed into norepinephrine through the action of DOPA decarboxylase and is used for treating neurogenic orthostatic hypotension and norepinephrine deficiency. It also has potential therapeutic applications for treating amyloid pathology.
Uses
Used in Pharmaceutical Industry:
Droxidopa is used as an antiparkinsonian agent for improving symptoms such as retropulsion, dysarthria, and muscular rigidity in Parkinsonian patients when added to existing levodopa/decarboxylase inhibitor therapy.
Used in Neurological Treatment:
Droxidopa is used as a treatment for neurogenic orthostatic hypotension, as it increases norepinephrine levels in the brain and helps improve blood pressure regulation.
Used in Clinical Trial Studies:
L-DOPS has been administered in clinical trial studies for mice with amyloid pathology, as it mediates the reduction of amyloid plaques and could have therapeutic potential for treating amyloid-related conditions.
Used in Drug Development:
Droxidopa is used as a psychoactive drug and acts as a prodrug to the neurotransmitters norepinephrine (noradrenaline) and epinephrine (adrenaline), with potential applications in the development of new medications for various neurological and psychiatric disorders.
Originator
Sumitomo (Japan)
Biochem/physiol Actions
L-DOPS is a norepinephrine precursor in vivo.
Check Digit Verification of cas no
The CAS Registry Mumber 23651-95-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,3,6,5 and 1 respectively; the second part has 2 digits, 9 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 23651-95:
(7*2)+(6*3)+(5*6)+(4*5)+(3*1)+(2*9)+(1*5)=108
108 % 10 = 8
So 23651-95-8 is a valid CAS Registry Number.
InChI:InChI=1/C9H11NO5/c10-7(9(14)15)8(13)4-1-2-5(11)6(12)3-4/h1-3,7-8,11-13H,10H2,(H,14,15)/t7-,8-/m0/s1
