23659-87-2 Usage
Description
4,6-Dimethoxyindole is an organic compound belonging to the indole family, characterized by the presence of two methoxy groups at the 4th and 6th positions of the indole ring. It is a versatile indole derivative with a wide range of applications in various industries due to its unique chemical properties and reactivity.
Uses
Used in Pharmaceutical Industry:
4,6-Dimethoxyindole is used as a reactant for the preparation of methoxy-substituted (benzyl)indolebutenoic acids, which exhibit HIV-1 integrase strand-transfer inhibition. This makes it a valuable compound in the development of antiretroviral drugs for the treatment of HIV/AIDS.
Used in Antimitotic Applications:
4,6-Dimethoxyindole is used as a reactant for the preparation of benzyl trimethoxyindoles, which serve as antimitotic agents. These compounds can disrupt cell division, making them potential candidates for the development of anticancer drugs.
Used in Antibacterial Applications:
4,6-Dimethoxyindole is used as a reactant for the preparation of antibacterial agents. Its unique chemical structure allows for the development of new compounds with potent antibacterial properties, which can be useful in the fight against antibiotic-resistant bacteria.
Used in Antitumor Applications:
4,6-Dimethoxyindole is used as a reactant for the preparation of pyridocarbazoles and pyrrolocarbazole analogs, which have been shown to possess anti-tumor activity. These compounds can potentially be developed into new therapeutic agents for the treatment of various types of cancer.
Used in Neuropharmacology:
4,6-Dimethoxyindole is used as a reactant for the preparation of methoxy-substituted N1-benzenesulfonylindole analogs, which act as human 5-HT6 serotonin receptor ligands. These compounds can modulate the activity of the 5-HT6 receptor, making them potential candidates for the development of drugs targeting neurological and psychiatric disorders.
Check Digit Verification of cas no
The CAS Registry Mumber 23659-87-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,3,6,5 and 9 respectively; the second part has 2 digits, 8 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 23659-87:
(7*2)+(6*3)+(5*6)+(4*5)+(3*9)+(2*8)+(1*7)=132
132 % 10 = 2
So 23659-87-2 is a valid CAS Registry Number.
InChI:InChI=1/C10H11NO2/c1-12-7-5-9-8(3-4-11-9)10(6-7)13-2/h3-6,11H,1-2H3
23659-87-2Relevant articles and documents
β-Amino alcohols from anilines and ethylene glycol through heterogeneous Borrowing Hydrogen reaction
Llabres-Campaner, Pedro J.,Ballesteros-Garrido, Rafael,Ballesteros, Rafael,Abarca, Belén
supporting information, p. 5552 - 5561 (2017/08/22)
Borrowing Hydrogen (BH), also called Hydrogen Autotransfer (HA), reaction with neat ethylene glycol represents a key step in the preparation of β-amino alcohols. However, due to the stability of ethylene glycol, mono-activation has rarely been achieved. Herein, a combination of Pd/C and ZnO is reported as heterogeneous catalyst for this BH/HA reaction. This system results in an extremely air and moisture stable, and economic catalyst able to mono-functionalize ethylene glycol in water, without further activation of the diol. In this work, different diols and aromatic amines have been explored affording a new approach towards amino alcohols. This study reveals how the combination of two solid species can afford interesting catalytic properties in heterogeneous phase. ZnO activates ethylene glycol while Pd/C is the responsible of the BH/HA cycle. This catalytic system has also been found useful to dehydrogenate indoles affording indolines that undergo in situ BH/HA cycle prior to re-aromatization, representing a tandem heterogeneous process.
SYNTHESIS OF MACROCYCLIC LIGANDS CONTAINING THE INDOLE RING SYSTEM
Black, David St. C.,Rothnie, Neil E.,Wong, Laurence C. H.
, p. 1883 - 1886 (2007/10/02)
2,7-Diformyl-3-methyl-4,6-dimethoxyindole (6) has been synthesized and converted by metal template reactions into the macrocyclic complexes (10-12).
