2367-17-1

Basic information

• Product Name: 6-fluoro-2,3,4,9-tetrahydro-1H-carbazole
• Synonyms: 6-fluoro-2,3,4,9-tetrahydro-1H-carbazole
• CAS NO: 2367-17-1
• Molecular Formula: C₁₂H₁₂FN
• Molecular Weight: 189.2287832
• Mol File: 2367-17-1.mol
• Article Data: 23

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 6-fluoro-2,3,4,9-tetrahydro-1H-carbazole(CAS DataBase Reference)
• NIST Chemistry Reference: 6-fluoro-2,3,4,9-tetrahydro-1H-carbazole(2367-17-1)
• EPA Substance Registry System: 6-fluoro-2,3,4,9-tetrahydro-1H-carbazole(2367-17-1)

Safety Data

• Hazardous Substances Data: 2367-17-1(Hazardous Substances Data)

Usage

General Description

6-Fluoro-2,3,4,9-tetrahydro-1H-carbazole is a chemical compound that belongs to the class of carbazole derivatives. It is a heterocyclic organic compound with a fluorine atom substituted at the 6-position of the carbazole ring. 6-fluoro-2,3,4,9-tetrahydro-1H-carbazole has potential applications in the field of organic synthesis and pharmaceutical research due to its unique structural properties. Carbazole derivatives have been studied for their diverse biological activities, including as anti-inflammatory, anti-cancer, and anti-microbial agents. The addition of a fluorine atom to the carbazole structure can potentially modify its chemical and biological properties, making it a subject of interest for further research and development in the pharmaceutical industry.

Upstream product

• 367-21-5 3-chloro-4-fluorophenylamine 
• 108-94-1 cyclohexanone 
• 1202391-84-1 tert-butyl 2-(4-fluorophenyl)hydrazine-1-carboxylate 
• 286-20-4 cyclohexane-1,2-epoxide 
• 371-40-4 4-fluoroaniline 
• 371-14-2 4-fluorophenylhydrazine 
• 823-85-8 4-fluorophenyhydrazine hydrochloride 
• 588-54-5 cyclohexanone-(4-fluoro-phenylhydrazone) 

Downstream Products

• 391-45-7 3-fluoro-9H-carbazole 

Relevant articles and documents

SBA-15-Pr-SO3H catalyzed one-pot synthesis of indole derivatives via Fischer indole pathway

In this work, an efficient, user-friendly, and simple procedure was reported for the preparation of indole derivatives catalyzed by the heterogeneous SBA-15-Pr-SO3H via Fischer indole pathway. The title compounds were synthesized from various arylhydrazines and ketones in the presence of 3 mol% of the catalyst in the refluxing ethanol.

Tetrahydrocarbazoles by mechanochemical Fischer indolisation

The Fischer indolisation (FI) typically proceeds in the presence of a Br?nsted or Lewis acid in an organic solvent at elevated temperatures. Herein, we report that tetrahydrocarbazoles (THCs) are accessible by mechanochemical FI at ambient temperature. Using phenylhydrazine hydrochlorides in the presence of silica is critical for this solid-state variant of the FI.

PYRIDINE BASED IONIC FLUORIDE FOR CATALYZING INDOLE AND TETRAZOLE FORMATION

A pyridine based ionic liquid with a fluoride counter anion which catalyzes Fischer indole reaction and click chemistry. Methods of preparing the ionic liquid, and methods of utilizing the ionic liquid as a catalyst to synthesize indoles/indolenines and tetrazoles are also provided.