23697-36-1Relevant articles and documents
Bis(dimethylsulfoxide)carbonateplatinum(II), a new synthon for a low-impact, versatile synthetic route to anticancer Pt carboxylates
Bergamini, Paola,Marvelli, Lorenza,Ferretti, Valeria,Gemmo, Chiara,Gambari, Roberto,Hushcha, Yekatsiaryna,Lampronti, Ilaria
supporting information, p. 10752 - 10760 (2016/07/07)
The work describes a new low-impact synthetic route to Pt(ii)-carboxylate complexes, a class of compounds provided with established anticancer activity. The process is based on the ligand substitution on [PtCO3(Me2SO-S)2] (1), a new synthon that can be easily prepared in water with high yield, is stable as a solid, and is reactive in solution where all its ligands can be easily replaced. It reacts with acidic O-donors releasing CO2 as the only side-product, whose development also supplies a driving force toward the products. The substitution of carbonate led to new Pt-DMSO carboxylate complexes 2-4, while the total substitution of the ligands of complex 1 gave new Pt-phosphino carboxylates 5-9 in high yields. The X-ray crystal structures of complexes [Pt(d(-)-quinate-O,O′)(Me2SO-S)2] (3), [Pt(salicylate)(Me2SO-S)2] (4) and [Pt(salicylate)(PPh3)2] (6) were determined. The tests of the antiproliferative activity of complexes 1-9 on two human tumoral cell lines, A2780 (cisplatin-sensitive) and SKOV-3 (cisplatin-resistant), showed that the PTA (PTA = 1,3,5-triaza-7-phosphaadamantane) complexes 7-9 were the most active on both cell lines.
REACTIONS OF DIPHOSPHINEPLATINUM(II) OXALATE COMPLEXES WITH PHENYLACETYLENE. FORMATION OF PHENYLALKYNYLPLATINUM COMPLEXES
Anderson, Gordon K.,Lumetta, Gregg J.
, p. 257 - 264 (2007/10/02)
reacts thermally with PhCCH to produce CPh)2(dppe)>, which has been prepared by alternative routes.Similar treatment of initially produces CPh)2(dpmm)>, which rearranges to give cis,cis-CPh)4(μ-dppm)2>.Reaction of with PhCCH/KOH/18-crown-6, or with (PhCC)SnMe3, gives CPh)2(dpmm)>, which may be converted to the cis,cis-dimer by addition of oxalic acid.Ultraviolet irradiation or refluxing with a trace amount of dppm converts CPh)2(dppm)> to trans,trans-CPh)4(μ-dppm)2>, but the cis,cis-dimer is stable under these conditions. (L = PPh3, PEt3) complexes also react thermally with PhCCH to yield CPh)2L2> species.
