237394-34-2

Basic information

• Product Name: 2-[(adamantan-1-yloxy)-(1-benzyloxycarbonylamino-ethyl)-phosphinoylmethyl]-5-phenyl-pentanoic acid ethyl ester
• Synonyms: 2-[(adamantan-1-yloxy)-(1-benzyloxycarbonylamino-ethyl)-phosphinoylmethyl]-5-phenyl-pentanoic acid ethyl ester
• CAS NO: 237394-34-2
• Molecular Weight: 595.716
• Mol File: 237394-34-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-[(adamantan-1-yloxy)-(1-benzyloxycarbonylamino-ethyl)-phosphinoylmethyl]-5-phenyl-pentanoic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[(adamantan-1-yloxy)-(1-benzyloxycarbonylamino-ethyl)-phosphinoylmethyl]-5-phenyl-pentanoic acid ethyl ester(237394-34-2)
• EPA Substance Registry System: 2-[(adamantan-1-yloxy)-(1-benzyloxycarbonylamino-ethyl)-phosphinoylmethyl]-5-phenyl-pentanoic acid ethyl ester(237394-34-2)

Safety Data

• Hazardous Substances Data: 237394-34-2(Hazardous Substances Data)

Upstream product

• 108327-37-3 [1-[[(phenylmethoxy)carbonyl]amino]ethyl]phosphinic acid 
• 27356-88-3 ethyl 2-methylene-5-phenylpentanoate 
• 768-90-1 1-Adamantyl bromide 
• 237394-20-6 2-[(1-benzyloxycarbonylamino-ethyl)-hydroxy-phosphinoylmethyl]-5-phenyl-pentanoic acid ethyl ester 

Downstream Products

• 237394-47-7 2-[(adamantan-1-yloxy)-(1-benzyloxycarbonylamino-ethyl)-phosphinoylmethyl]-5-phenyl-pentanoic acid 

Relevant articles and documents

Phosphinic pseudo-tripeptides as potent inhibitors of matrix metalloproteinases: A structure-activity study

Several phosphinic pseudo-tripeptides of general formula R-XaaΨ(PO2- CH2)Xaa'-Yaa'-NH2 were synthesized and evaluated for their in vitro activities to inhibit stromelysin-3, gelatinases A and B, membrane type-1 matrix metalloproteinase, collagenases 1 and 2, and matrilysin. With the exception of collagenase-1 and matrilysin, phosphinic pseudo-tripeptides behave as highly potent inhibitors of matrix metalloproteinases, provided they contain in P1' position an unusual long aryl-alkyl substituent. Study of structure-activity relationships regarding the influence of the R and Xaa' substituents in this series may contribute to the design of inhibitors able to block only a few members of the matrix metalloproteinase family.