237427-27-9

Basic information

• Product Name: 4,5-Heptadien-2-one, 3-hydroxy-3-methyl-, (4S)- (9CI)
• Synonyms: 4,5-Heptadien-2-one, 3-hydroxy-3-methyl-, (4S)- (9CI)
• CAS NO: 237427-27-9
• Molecular Formula: C8H12O2
• Molecular Weight: 140.17968
• Product Categories: ACETYLGROUP
• Mol File: 237427-27-9.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4,5-Heptadien-2-one, 3-hydroxy-3-methyl-, (4S)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 4,5-Heptadien-2-one, 3-hydroxy-3-methyl-, (4S)- (9CI)(237427-27-9)
• EPA Substance Registry System: 4,5-Heptadien-2-one, 3-hydroxy-3-methyl-, (4S)- (9CI)(237427-27-9)

Safety Data

• Hazardous Substances Data: 237427-27-9(Hazardous Substances Data)

Upstream product

• 42969-65-3 (R)-(+)-3-butyn-2-ol 
• 14088-58-5 3-diazo-2-butanone 
• 2028-63-9 but-3-yn-2-ol 

Relevant articles and documents

Rhodium carbenoid-initiated Claisen rearrangement: scope and mechanistic observations.

[formula: see text] It has been shown that alpha-diazoketones react with allylic alcohols in the presence of Rh(II) catalysts to furnish intermediate enols which subsequently undergo Claisen rearrangement to alpha-hydroxyketones. Herein we report (1) studies into the mechanism of this transformation which establish that Claisen rearrangement is neither rhodium- nor acid-catalyzed but a reaction intrinsic to the intermediate enols that proceeds at a rate governed by enol substituents (R3, R4, R5) and (2) the reaction of alpha-diazoketones with propargylic alcohols and preliminary investigations into its scope and mechanism.