237432-12-1

Basic information

• Product Name: 3-chloro-4-thiomorpholin-4-ylmethyl-phenylamine
• Synonyms: 3-chloro-4-thiomorpholin-4-ylmethyl-phenylamine
• CAS NO: 237432-12-1
• Molecular Weight: 242.772
• Mol File: 237432-12-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-chloro-4-thiomorpholin-4-ylmethyl-phenylamine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-chloro-4-thiomorpholin-4-ylmethyl-phenylamine(237432-12-1)
• EPA Substance Registry System: 3-chloro-4-thiomorpholin-4-ylmethyl-phenylamine(237432-12-1)

Safety Data

• Hazardous Substances Data: 237432-12-1(Hazardous Substances Data)

Upstream product

• 42533-63-1 1-(bromomethyl)-2-chloro-4-nitrobenzene 
• 237432-06-3 4-(2-chloro-4-nitro-benzyl)-thiomorpholine 
• 121-86-8 2-chloro-4-nitrotoluene 

Relevant articles and documents

N-[4-(1,1'-biphenylyl)methyl]-4-(4-thiomorpholinylmethyl) benzenamines, a new class of synthetic antituberculosis agents active against Mycobacterium avium

Various N-derivatives of 4-(4-thiomorpholinyl)aniline and 4-(4- thiomorpholinylmethyl)aniline were synthesized and tested for in vitro antibacterial activities against Mycobacterium avium CIP 103317 and other mycobacteria including M. tuberculosis CIP 103471. Appropriate substituents were introduced at the nitrogen of aniline portion in order to exploit their potential antimycobacterial activities. Only derivatives with the biphenylylmethyl group bound to the 4-(4-thiomorpholinylmethyl)aniline moiety were found to possess appreciable antibacterial activities against atypical mycobacteria and M. tuberculosis. Several compounds (7c-g and 7j) were two and sixteen times more potent than azithromycin and isoniazid, respectively, in the in vitro assays against M. avium.