237435-16-4

Basic information

• Product Name: 2,4-DICHLORO-3-AMINO-6-BROMOPYRIDINE
• Synonyms: 2,4-DICHLORO-3-AMINO-6-BROMOPYRIDINE;6-bromo-2,4-dichloropyridin-3-amine;6-bromo-2,4-dichloro-3-Pyridinamine;3-Pyridinamine,6-bromo-2,4-dichloro-
• CAS NO: 237435-16-4
• Molecular Formula: C₅H₃BrCl₂N₂
• Molecular Weight: 241.90072
• Product Categories: Pyridine
• Mol File: 237435-16-4.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 301.229 °C at 760 mmHg
• Flash Point: 135.979 °C
• Appearance: /
• Density: 1.934±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: -2.02±0.10(Predicted)
• CAS DataBase Reference: 2,4-DICHLORO-3-AMINO-6-BROMOPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-DICHLORO-3-AMINO-6-BROMOPYRIDINE(237435-16-4)
• EPA Substance Registry System: 2,4-DICHLORO-3-AMINO-6-BROMOPYRIDINE(237435-16-4)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 237435-16-4(Hazardous Substances Data)

Usage

General Description

2,4-DICHLORO-3-AMINO-6-BROMOPYRIDINE is a chemical compound with the molecular formula C5H4BrCl2N3. It is a pyridine derivative that consists of a pyridine ring with chlorine and bromine atoms at the 2 and 6 positions, and an amino group at the 3 position. 2,4-DICHLORO-3-AMINO-6-BROMOPYRIDINE is commonly used as an intermediate in the synthesis of various pharmaceuticals and agrochemicals. It has been found to exhibit herbicidal and fungicidal properties, making it useful in the development of crop protection products. Additionally, it has potential applications in the field of medicinal chemistry for the development of new drugs.

Upstream product

• 173772-63-9 2,4-dichloropyridin-3-ylamine 
• 5975-12-2 2,4-dichloro-3-nitro-pyridine 
• 89282-12-2 2,4-dihydroxy-3-nitropyridine 
• 626-03-9 3-deazauracil 

Downstream Products

• 237435-17-5 3-amino-4-chloro-6-methyl-2-(2-phenylethynyl)pyridine 
• 1026076-88-9 7-chloro-5-methyl-2-phenylpyrrolo[3,2-b]pyridine 
• 179056-98-5 3-amino-2,4-dichloro-6-methylpyridine 

Relevant articles and documents

Scaffold morphing leading to evolution of 2,4-diaminoquinolines and aminopyrazolopyrimidines as inhibitors of the ATP synthesis pathway

The success of bedaquiline as an anti-tubercular agent for the treatment of multidrug-resistant tuberculosis has validated the ATP synthesis pathway and in particular ATP synthase as an attractive target. However, limitations associated with its use in the clinic and the drug-drug interactions with rifampicin have prompted research efforts towards identifying alternative ATP synthesis inhibitors with differentiated mechanisms of action. A biochemical assay was employed to screen AstraZeneca's corporate compound collection to identify the inhibitors of mycobacterial ATP synthesis. The high-throughput screening resulted in the identification of 2,4-diaminoquinazolines as inhibitors of the ATP synthesis pathway. A structure-activity relationship for the quinazolines was established and the knowledge was utilized to morph the quinazoline core into quinoline and pyrazolopyrimidine to expand the scope of chemical diversity. The morphed scaffolds exhibited a 10-fold improvement in enzyme potency and over 100-fold improvement in selectivity against inhibition of mammalian mitochondrial ATP synthesis. These novel compounds were bactericidal and demonstrated growth retardation of Mycobacterium tuberculosis in the acute mouse model of tuberculosis infection.

Compounds and methods which modulate feeding behavior and related diseases

There are provided compounds, compositions and methods of use thereof in the modulation of feeding behavior, obesity, diabetes, cancer (tumor), inflammatory disorders, depression, stress related disorders, Alzheimer's disease and other disease conditions.