23775-39-5

Basic information

• Product Name: 4-ETHYL-CYCLOHEXYLAMINE
• Synonyms: 4-ETHYLCYCLOHEXANAMINE;4-ETHYL-CYCLOHEXYLAMINE;AKOS B018386;CHEMBRDG-BB 3018386;ART-CHEM-BB B018386;4-Ethylcyclohexaneamine;4-Ethylcyclohexylamine 95%;1-Amino-4-ethylcyclohexane
• CAS NO: 23775-39-5
• Molecular Formula: C₈H₁₇N
• Molecular Weight: 127.23
• Mol File: 23775-39-5.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 75 °C
• Flash Point: 36.4°C
• Appearance: /
• Density: 0.839g/cm³
• Vapor Pressure: 1.8mmHg at 25°C
• Refractive Index: 1.447
• PKA: 10.58±0.70(Predicted)
• CAS DataBase Reference: 4-ETHYL-CYCLOHEXYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-ETHYL-CYCLOHEXYLAMINE(23775-39-5)
• EPA Substance Registry System: 4-ETHYL-CYCLOHEXYLAMINE(23775-39-5)

Safety Data

• Hazard Codes: C,Xi,Xn
• Statements: 22-36
• Safety Statements: 26
• HazardClass: IRRITANT
• Hazardous Substances Data: 23775-39-5(Hazardous Substances Data)

Usage

General Description

4-Ethyl-cyclohexylamine is a chemical compound with the molecular formula C8H17N. It is a clear to slightly yellow liquid with a strong and unpleasant odor. It is primarily used as an intermediate in the production of pharmaceuticals, pesticides, and other organic compounds. It can also be used as a corrosion inhibitor in water treatment processes and as a catalyst in chemical reactions. 4-Ethyl-cyclohexylamine is considered to be moderately toxic and can cause irritation to the skin, eyes, and respiratory system upon exposure. It should be handled and stored with proper safety measures in place to prevent accidents and exposure.

InChI:InChI=1/C8H17N/c1-2-7-3-5-8(9)6-4-7/h7-8H,2-6,9H2,1H3

Upstream product

• 17716-05-1 4-(Ethyl)cyclohexanone oxime 
• 5441-51-0 4-ethylcyclohexanone 
• 123-07-9 4-Ethylphenol 
• 178363-93-4 C₁₅H₂₃N 

Relevant articles and documents

Discovery and Optimization of a Compound Series Active against Trypanosoma cruzi, the Causative Agent of Chagas Disease

Chagas disease is caused by the protozoan parasite Trypanosoma cruzi. It is endemic in South and Central America and recently has been found in other parts of the world, due to migration of chronically infected patients. The current treatment for Chagas disease is not satisfactory, and there is a need for new treatments. In this work, we describe the optimization of a hit compound resulting from the phenotypic screen of a library of compounds against T. cruzi. The compound series was optimized to the level where it had satisfactory pharmacokinetics to allow an efficacy study in a mouse model of Chagas disease. We were able to demonstrate efficacy in this model, although further work is required to improve the potency and selectivity of this series.

The Rhodium Catalysed Direct Conversion of Phenols to Primary Cyclohexylamines

Cyclohexylamines are important intermediates in chemical industry, which are currently produced from petrochemical sources. Phenols, however, are an attractive sustainable feedstock. We here demonstrate the transformation of phenols with ammonia to primary cyclohexylamines. In contrast to previously reported chemistry which used palladium catalysts, we here show that rhodium is an excellent catalyst for the formation of primary cyclohexylamines. Different parameters were studied and it was shown that the reaction is applicable to a scope of phenolic compounds providing high selectivity.