23779-14-8

Basic information

• Product Name: phenyl [4-(trifluoromethyl)phenyl]carbamate
• CAS NO: 23779-14-8
• Molecular Formula: C₁₄H₁₀F₃NO₂
• Molecular Weight: 281.2299
• Mol File: 23779-14-8.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 322.414°C at 760 mmHg
• Flash Point: 148.791°C
• Density: 1.353g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.559
• CAS DataBase Reference: phenyl [4-(trifluoromethyl)phenyl]carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: phenyl [4-(trifluoromethyl)phenyl]carbamate(23779-14-8)
• EPA Substance Registry System: phenyl [4-(trifluoromethyl)phenyl]carbamate(23779-14-8)

Safety Data

• Hazardous Substances Data: 23779-14-8(Hazardous Substances Data)

Upstream product

• 4930-03-4 phenyl N-phenylcarbamate 
• 2926-29-6 Langlois reagent 
• 455-14-1 4-trifluoromethylphenylamine 
• 1885-14-9 phenyl chloroformate 
• 1548-13-6 p-trifluoromethyl-phenylisocyanate 
• 108-95-2 phenol 

Downstream Products

• 1596368-65-8 (E)-1-{[(7-dimethylamino)-2-oxo-2H-chromen-3-yl]methylidene}-4-(4-trifluoromethylphenyl)semicarbazone 
• 1245737-91-0 8-chloro-6-fluoro-N-[4-(trifluoromethyl)phenyl]-3,4-dihydrospiro[chromene-2,4'-piperidine]-1'-carboxamide 
• 1245737-81-8 8-bromo-N-[4-(trifluoromethyl)phenyl]-3,4-dihydrospiro[chromene-2,4'-piperidine]-1'-carboxamide 
• 1245738-05-9 (±)-8-bromo-4-hydroxy-N-[4-(trifluoromethyl)phenyl]-3,4-dihydrospiro[chromene-2,4'-piperidine]-1'-carboxamide 
• 1245738-60-6 8-bromo-4-oxo-N-[4-(trifluoromethyl)phenyl]-3,4-dihydrospiro[chromene-2,4'-piperidine]-1'-carboxamide 
• 1245738-02-6 (±)-8-chloro-4-hydroxy-N-[4-(trifluoromethyl)phenyl]-3,4-dihydrospiro[chromene-2,4'-piperidine]-1'-carboxamide 
• 1245738-01-5 8-chloro-4-oxo-N-[4-(trifluoromethyl)phenyl]-3,4-dihydrospiro[chromene-2,4'-piperidine]-1'-carboxamide 
• 1245738-06-0 (±)-8-fluoro-4-hydroxy-N-[4-(trifluoromethyl)phenyl]-3,4-dihydrospiro[chromene-2,4'-piperidine]-1'-carboxamide 
• 1245738-61-7 8-fluoro-4-oxo-N-[4-(trifluoromethyl)phenyl]-3,4-dihydrospiro[chromene-2,4'-piperidine]-1'-carboxamide 
• 1305743-36-5 C₁₀H₁₁F₃N₂O₂ 
• 1245737-77-2 8-chloro-N-[4-(trifluoromethyl)phenyl]-3,4-dihydrospiro[chromene-2,4'-piperidine]-1'-carboxamide 

Relevant articles and documents

Photoredox-Catalyst-Enabled para-Selective Trifluoromethylation of tert-Butyl Arylcarbamates

The direct incorporation of a trifluoromethyl group on an aromatic ring using a radical pathway has been extensively investigated. However, the direct highly para-selective C?H trifluoromethylation of a class of arenes has not been achieved. In this study, we report a light-promoted 4,5-dichlorofluorescein (DCFS)-enabled para-selective C?H trifluoromethylation of arylcarbamates using Langlois reagent. The preliminary mechanistic study revealed that the activated organic photocatalyst coordinated with the arylcarbamate led to para-selective C?H trifluoromethylation. Ten-gram scale reaction performs well highlighting the synthetic importance of this new protocol.

Benzothiazole derivatives and their uses

The present invention relates to benzothiazole derivatives and their uses, specifically to compounds shown in formula I or stereoisomers thereof and pharmaceutically acceptable salts, solvates or prodrugs thereof, methods of preparation thereof, and pharmaceutical compositions containing the compounds, wherein the substituentsR1,R2,R8 , X, Y, Z, Q have the meaning given in the instruction manual. The present invention further relates to the application of compounds of formula I in the preparation of drugs for the treatment and / or prevention of sEH-mediated diseases, in particular in the preparation of drugs for the treatment of inflammatory diseases, cardiovascular and cerebrovascular diseases, diabetes mellitus, diabetic complications, diabetes-related diseases, fibrotic diseases, neurological and psychiatric diseases, pain, ulcerative diseases and the like.

Synthesis and biological potentials of 5-aryl-n-[4-(Trifluoromethyl) phenyl]-1,3,4-oxadiazol-2-amines

Oxadiazoles are an important class of heterocyclic compounds, having broad-spectrum activity. They were also reported as anticancer, and antioxidant agents, hence it is of significant importance to explore new oxadiazoles. A series of eleven (5-aryl-N-[4-