23819-87-6

Basic information

• Product Name: 5-BROMO-4,6-DIMETHYL-2-OXO-1,2-DIHYDRO-3-PYRIDINECARBONITRILE
• Synonyms: 5-BROMO-4,6-DIMETHYL-2-OXO-1,2-DIHYDRO-3-PYRIDINECARBONITRILE;5-BROMO-4,6-DIMETHYL-2-HYDROXYPYRIDINE-3-CARBONITRILE;5-Bromo-3-cyano-2-hydroxy-4,6-dimethylpyridine, 98%;5-Bromo-1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinecarbonitrile;5-Bromo-2-hydroxy-4,6-dimethylpyridine-3-carbonitrile;5-BroMo-4,6-diMethyl-2-oxo-1,2-dihydropyridine-3-carbonitrile
• CAS NO: 23819-87-6
• Molecular Formula: C₈H₇BrN₂O
• Molecular Weight: 227.06
• Mol File: 23819-87-6.mol
• Article Data: 9

Chemical Properties

• Melting Point: 263-266°C
• Boiling Point: 301℃
• Flash Point: 136℃
• Appearance: /
• Density: 1.61
• Vapor Pressure: 0.00109mmHg at 25°C
• Refractive Index: 1.588
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 7.00±0.10(Predicted)
• CAS DataBase Reference: 5-BROMO-4,6-DIMETHYL-2-OXO-1,2-DIHYDRO-3-PYRIDINECARBONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-BROMO-4,6-DIMETHYL-2-OXO-1,2-DIHYDRO-3-PYRIDINECARBONITRILE(23819-87-6)
• EPA Substance Registry System: 5-BROMO-4,6-DIMETHYL-2-OXO-1,2-DIHYDRO-3-PYRIDINECARBONITRILE(23819-87-6)

Safety Data

• Statements: 20/21/22-36/37/38
• Safety Statements: 9-26-36/37
• RIDADR: UN3439
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 23819-87-6(Hazardous Substances Data)

Usage

Chemical Properties

White solid

InChI:InChI=1/C8H7BrN2O/c1-4-6(3-10)8(12)11-5(2)7(4)9/h1-2H3,(H,11,12)

Upstream product

• 123-54-6 acetylacetone 
• 769-28-8 3-Cyano-4,6-dimethyl-2(1H)-pyridon 
• 769-28-8 2-hydroxy-4,6-dimethyl-3-carbonitrile 

Downstream Products

• 89694-55-3 5-bromo-4,6-dimethylpyridin-2-ol 
• 941693-40-9 2-(3-(4-methoxybenzyloxy)prop-1-ynyl)-4,6-dimethylpyridine-3,5-dicarbonitrile 
• 941693-43-2 2-(3-(4-methoxybenzyloxy)propyl)-4,6-dimethylpyridine-3,5-dicarbonitrile 
• 941693-23-8 2-(3-(4-methoxybenzyloxy)propyl)-4,6-dimethylpyridine-3,5-dicarbaldehyde 
• 42951-65-5 5-bromo-4,6-dimethyl-1⁽²⁾H-pyrazolo[3,4-b]pyridin-3-ylamine 
• 1425934-43-5 C₂₇H₂₁BrN₂O₂ 
• 1425934-44-6 2-(5-bromo-4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)-4,4-diphenyl-4H-3,1-benz-oxazinium perchlorate 
• 1425934-39-9 C₂₇H₂₂BrN₃O 
• 1425934-40-2 2-(5-bromo-4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)-4,4-diphenyl-3,4-dihydroquinazolinium perchlorate 
• 42951-71-3 6-chloro-3-bromo-2,4-dimethylpyridine-5-carbonitrile 
• 93350-07-3 Methyl 4,6-Dimethyl-5-phenylnicotinate 
• 93350-01-7 5-bromo-4,6-dimethylpyridine-3-carboxylic acid 
• 63644-86-0 5-Bromo-3-cyano-4,6-dimethylpyridine 

Relevant articles and documents

CARDIOTROPIC ACTIVITY OF PYRIDIN--2(1H)-ONES

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Synthesis and reactions of 3-cyano-4,6-dimethyl-2-pyridone

Rapid synthesis of 3-cyano-4,6-dimethyl-2-pyridone 3, using piprazine as a catalyst was reported. X-ray data of the 4,6-dimethyl-2-oxo-1,2-dihydropyridine- 3-carbonitrile exhibited its oxo form. Synthesis of isoquinolinecarbonitrile and pyridylpyridazine using compound 3 was investigated. Reactivity of the synthesized pyridone toward different organic reagents was also studied.

Total synthesis of anibamine, a novel natural product as a chemokine receptor CCR5 antagonist

The total synthesis of anibamine, the first and only natural product known as a chemokine receptor OCR5 antagonist, is reported herein. Anibamine was synthesized from acetylacetone and cyanoacetamide in 10 steps.