23826-47-3

Basic information

• Product Name: 2-METHYLAMINO-1-PHENYL-ETHANONE HYDROCHLORIDE
• Synonyms: Ethanone, 2-(methylamino)-1-phenyl-, hydrochloride (1:1)
• CAS NO: 23826-47-3
• Molecular Formula: C₉H₁₁NO*ClH
• Molecular Weight: 185.653
• Mol File: 23826-47-3.mol
• Article Data: 6

Chemical Properties

• Melting Point: 219 °C
• Boiling Point: 244.6°Cat760mmHg
• Flash Point: 104°C
• Appearance: /
• Density: 1.019g/cm³
• CAS DataBase Reference: 2-METHYLAMINO-1-PHENYL-ETHANONE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-METHYLAMINO-1-PHENYL-ETHANONE HYDROCHLORIDE(23826-47-3)
• EPA Substance Registry System: 2-METHYLAMINO-1-PHENYL-ETHANONE HYDROCHLORIDE(23826-47-3)

Safety Data

• Hazardous Substances Data: 23826-47-3(Hazardous Substances Data)

Usage

General Description

2-Methylamino-1-phenyl-ethanone hydrochloride, also known as Methamphetamine hydrochloride, is a synthetic chemical compound that is a derivative of amphetamine. It is a psychoactive stimulant that affects the central nervous system, producing effects such as increased energy, alertness, and euphoria. It is used illicitly as a recreational drug due to its addictive properties and potential for abuse. The compound is a white, crystalline powder that is typically ingested orally, inhaled, or injected. It is classified as a Schedule II controlled substance in the United States due to its high potential for abuse and addiction. Long-term use of methamphetamine hydrochloride can lead to serious health issues such as cardiovascular problems, psychological disturbances, and cognitive impairments.

Upstream product

• 77184-10-2 1,1-dimethylethyl methyl(2-phenyl-2-oxoethyl)carbamate 
• 593-51-1 methylamine hydrochloride 
• 70-11-1 α-bromoacetophenone 
• 74-89-5 methylamine 
• 77914-73-9 1-phenyl-2-N-methylamino-3-hydroxy-3-(p-bromophenyl)-1-propanone hydrochloride 
• 74879-77-9 [(2S,3S)-1-Methyl-3-(3-nitro-phenyl)-aziridin-2-yl]-phenyl-methanone 
• 74300-26-8 [(2R,3R)-3-(4-Bromo-phenyl)-1-methyl-aziridin-2-yl]-phenyl-methanone 
• 74879-75-7 [(2R,3R)-3-(4-Chloro-phenyl)-1-methyl-aziridin-2-yl]-phenyl-methanone 
• 74300-28-0 ((2R,3R)-1-Methyl-3-p-tolyl-aziridin-2-yl)-phenyl-methanone 
• 6476-40-0 cis-1-methyl-2-benzoyl-3-phenylaziridine 
• 556-64-9 methyl thiocyanate 

Downstream Products

• 131910-98-0 1-(1-methyl-4-phenyl-1H-pyrrol-3-yl)ethan-1-one 
• 130202-79-8 (2R,3S)-2,3-Epoxy-N-methyl-N-phenacyl-3-phenylpropionamide 
• 1384979-20-7 benzyl (2-hydroxy-2-phenylethyl)(methyl)carbamate 
• 1258312-88-7 C₁₃H₁₃NO₂ 
• 25433-14-1 1-methyl-4-phenyl-1,3-dihydroimidazole-2-thione 
• 65-85-0 benzoic acid 
• 156742-54-0 1-methyl-3-phenyl<1>benzopyrano<4,3-b>pyrrol-4(1H)-one 
• 199474-12-9 1,6-Dimethyl-3-phenyl-1H-chromeno[2,3-b]pyrrol-4-one 
• 65058-52-8 N-methyl (S)-2-hydroxy-2-phenylethylamine 

Relevant articles and documents

COMPOSITIONS AND METHODS COMPRISING SUBSTITUTED 2-AMINOIMIDAZOLES

The present invention presents 2-(acylamino)imidazoles with therapeutic activity, including selective activity against cancer cells, and compositions comprising them. Methods of using and preparing the 2-(acylamino)imidazoles are also presented.

ZnCl2-promoted asymmetric hydrogenation of β-secondary-amino ketones catalyzed by a P-chiral rh-bisphosphine complex

A new catalytic system has been developed for the asymmetric hydrogenation of β-secondary-amino ketones using a highly efficient P-chiral bisphosphine-rhodium complex in combination with ZnCl2 as the activator of the catalyst. The chiral γ-secondary-amino alcohols were obtained in 90-94% yields, 90-99% enantioselectivities, and with high turnover numbers (up to 2000 S/C; S/C = substrate/catalyst ratio). A mechanism for the promoting effect of ZnCl2 on the catalytic system has been proposed on the basis of NMR spectroscopy and HRMS studies. This method was successfully applied to the asymmetric syntheses of three important drugs, (S)-duloxetine, (R)-fluoxetine, and (R)-atomoxetine, in high yields and with excellent enantioselectivities.

SYNTHESIS, STEREOCHEMISTRY, AND ISOMERIC TRANSFORMATIONS OF 4-ARYL-5-AROYL-2-METHYLTHIO-2-IMIDAZOLINES

The corresponding 4-aryl-5-aroyl-2-methylthio-2-imidazolines were obtained by the reaction of complexes of cis- and trans-3-aroylaziridines and boron trifluoride with methyl thiocyanate.It is shown on the basis of spectral data that the aziridine ring is opened regiospecifically at the C(2) atom and stereospecifically with inversion of the configuration.