2385-28-6

Basic information

• Product Name: 2,3-Piperazinedione,1-butyl-(7CI,9CI)
• Synonyms: 2,3-Piperazinedione,1-butyl-(7CI,9CI);1-BUTYLPIPERAZINE-2,3-DIONE;1-butyl-2,3-Piperazinedione
• CAS NO: 2385-28-6
• Molecular Formula: C₈H₁₄N₂O₂
• Molecular Weight: 170.21
• Product Categories: PIPERIDINE
• Mol File: 2385-28-6.mol
• Article Data: 4

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.083g/cm³
• Refractive Index: 1.474
• CAS DataBase Reference: 2,3-Piperazinedione,1-butyl-(7CI,9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-Piperazinedione,1-butyl-(7CI,9CI)(2385-28-6)
• EPA Substance Registry System: 2,3-Piperazinedione,1-butyl-(7CI,9CI)(2385-28-6)

Safety Data

• Hazardous Substances Data: 2385-28-6(Hazardous Substances Data)

Usage

General Description

2,3-Piperazinedione, 1-butyl-(7CI,9CI) is a chemical compound with the molecular formula C8H14N2O2. It is a cyclic amide and a piperazinedione derivative. 2,3-Piperazinedione,1-butyl-(7CI,9CI) is also known by its systematic name 1-butyl-2,3-diazinane-4,5-dione. It is used in organic synthesis and is a versatile intermediate for the production of various pharmaceuticals and agrochemicals. It is also a potential building block for novel materials and polymers. In addition, it has potential applications in the field of medicinal chemistry and drug discovery as a scaffold for the design of new compounds with biological activity.

InChI:InChI=1/C8H14N2O2/c1-2-3-5-10-6-4-9-7(11)8(10)12/h2-6H2,1H3,(H,9,11)

Upstream product

• 13880-27-8 trans-1,2-diaminohexane 
• 95-92-1 oxalic acid diethyl ester 
• 1375301-09-9 C₁₅H₂₀N₂O₂ 
• 19522-69-1 N-butylethylenediamine 

Downstream Products

• 1015005-45-4 methyl (4-butyl-2,3-dioxopiperazin-1-yl)(phenyl)acetate 

Relevant articles and documents

PIPERIDINE AND PYRROLIDINE BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE

The present invention is directed to compounds of formula (I) which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.

Aspartyl protease inhibitors

The present invention provides compounds having the formula: wherein R1, R′, R2, R3, R3′, R4, X1, X2 and X3 are as defined herein, and pharmaceutical compositions thereof. The present invention also provides methods of inhibiting proteases, more specifically aspartyl proteases. In certain embodiments, compounds inhibit BACE (β-site APP-cleaving enzyme), and thus are useful in the treatment or prevention of a disease characterized by β-amyloid deposits in the brain (including, but not limited to, Alzheimer's Disease). The present invention also provides methods for preparing compounds of the invention.