2385-87-7 Usage
General Description
1-[(9,10-Didehydro-6-methylergolin-8β-yl)carbonyl]pyrrolidine is a chemical compound that belongs to the ergoline alkaloid class. It is a derivative of the ergot alkaloid family and is structurally related to the compound ergotamine. 1-[(9,10-Didehydro-6-methylergolin-8β-yl)carbonyl]pyrrolidine has been studied for its potential pharmacological effects, particularly its activity on the central nervous system. Some research has suggested that it may act as a dopamine receptor agonist, which could have implications for its potential use in the treatment of neurological disorders. Additionally, its structural similarity to ergotamine suggests that it may also have vasoconstrictive properties, making it of potential interest for the treatment of migraine headaches. Further research is needed to fully understand the pharmacological properties and potential applications of 1-[(9,10-Didehydro-6-methylergolin-8β-yl)carbonyl]pyrrolidine.
Check Digit Verification of cas no
The CAS Registry Mumber 2385-87-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,3,8 and 5 respectively; the second part has 2 digits, 8 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 2385-87:
(6*2)+(5*3)+(4*8)+(3*5)+(2*8)+(1*7)=97
97 % 10 = 7
So 2385-87-7 is a valid CAS Registry Number.
InChI:InChI=1/C20H23N3O/c1-22-12-14(20(24)23-7-2-3-8-23)9-16-15-5-4-6-17-19(15)13(11-21-17)10-18(16)22/h4-6,9,11,14,18,21H,2-3,7-8,10,12H2,1H3/t14-,18-/m1/s1
2385-87-7Relevant articles and documents
Special ergolines efficiently inhibit the chemokine receptor CXCR3 in blood
Thoma, Gebhard,Baenteli, Rolf,Lewis, Ian,Jones, Darryl,Kovarik, Jiri,Streiff, Markus B.,Zerwes, Hans-Guenter
scheme or table, p. 4745 - 4749 (2011/09/16)
The structure-activity relationship of highly potent special ergolines which selectively block the chemokine receptor CXCR3 is reported. The most potent compounds showed IC50 values below 10 nM in both ligand binding and Ca2+-mobilization assays. However, these compounds were poorly active in an assay that measures receptor occupancy in blood. Introduction of polar substituents led to derivatives with IC50 values below 10 nM in this assay. Among them was compound 11a which showed both a favorable PK profile and cross reactivity with rodent CXCR3 making it a promising tool compound to further explore the role of CXCR3 in animal models.
