23873-65-6

Basic information

• Product Name: 3-[benzyl(methyl)amino]propanenitrile
• Synonyms: 3-[benzyl(methyl)amino]propanenitrile
• CAS NO: 23873-65-6
• Molecular Formula: C₁₁H₁₄N₂
• Molecular Weight: 174.24226
• Mol File: 23873-65-6.mol
• Article Data: 13

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-[benzyl(methyl)amino]propanenitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 3-[benzyl(methyl)amino]propanenitrile(23873-65-6)
• EPA Substance Registry System: 3-[benzyl(methyl)amino]propanenitrile(23873-65-6)

Safety Data

• Hazardous Substances Data: 23873-65-6(Hazardous Substances Data)

Upstream product

• 7677-24-9 trimethylsilyl cyanide 
• 693-05-0 N-(2-cyanoethyl)-N-methylamine 
• 100-44-7 benzyl chloride 
• 103-67-3 benzyl-methyl-amine 
• 542-76-7 3-Chloropropionitrile 
• 100-46-9 benzylamine 
• 57675-92-0 2-((benzyl(methyl)amino)methyl)isoindoline-1,3-dione 
• 372-09-8 cyanoacetic acid 
• 706-03-6 3-(benzylamino)propionitrile 
• 74-88-4 methyl iodide 
• 77-78-1 dimethyl sulfate 
• 107-13-1 acrylonitrile 

Downstream Products

• 1416162-65-6 C₂₃H₂₆N₂O₅ 
• 91904-86-8 N-[3-(benzyl-methyl-amino)-propyl]-glycolamide 
• 149692-49-9 3-(N-Benzyl-N-methylamino)propionsaeure 
• 13910-49-1 3(-N-methyl-N-benzylamino)propylamine 
• 25772-94-5 3-(N-Benzyl-N-methylamino)propionsaeureethylester 

Relevant articles and documents

KOtBu-Catalyzed Michael Addition Reactions Under Mild and Solvent-Free Conditions

Designed transition metal complexes predominantly catalyze Michael addition reactions. Inorganic and organic base-catalyzed Michael addition reactions have been reported. However, known base-catalyzed reactions suffer from the requirement of solvents, additives, high pressure and also side-reactions. Herein, we demonstrate a mild and environmentally friendly strategy of readily available KOtBu-catalyzed Michael addition reactions. This simple inorganic base efficiently catalyzes the Michael addition of underexplored acrylonitriles, esters and amides with (oxa-, aza-, and thia-) heteroatom nucleophiles. This catalytic process proceeds under solvent-free conditions and at room temperature. Notably, this protocol offers an easy operational procedure, broad substrate scope with excellent selectivity, reaction scalability and excellent TON (>9900). Preliminary mechanistic studies revealed that the reaction follows an ionic mechanism. Formal synthesis of promazine is demonstrated using this catalytic protocol.

Synthesis, Characterization and Catalytic Application of MCM 41 Supported Phenanthrolinium Dibromide Catalyst for Aza-Michael Addition Reaction in Aqueous Medium

Abstract: MCM-41 immobilized phenanthrolinium dibromide (phen-MCM-Br2) was easily prepared and applied as an efficient heterogeneous catalyst for aza-Michael addition of aromatic amines to α,β-unsaturated nitriles and nitro compounds in water. The catalyst was characterized by CHN, TGA, FT-IR, SEM, EDAX, XRD, BET, and TEM. It could be simply recovered and reused several times without significant loss of catalytic activity. Graphical Abstract: [Figure not available: see fulltext.]

Palladium nanoparticles in glycerol: A versatile catalytic system for C-X bond formation and hydrogenation processes

Palladium nanoparticles stabilised by tris(3-sulfophenyl)phosphine trisodium salt in neat glycerol have been synthesised and fully characterised, starting from both Pd(II) and Pd(0) species. The versatility of this innovative catalytic colloidal solution has been proved by its efficient application in C-X bond formation processes (X=C, N, P, S) and C-C multiple bond hydrogenation reactions. The catalytic glycerol phase could be recycled more than ten times, preserving its activity and selectivity. The scope of each of these processes has demonstrated the power of the as-prepared catalyst, isolating the corresponding expected products in yields higher than 90%. The dual catalytic behaviour of this glycerol phase, associated to the metallic nanocatalysts used in wet medium (molecular- and surface-like behaviour), has allowed attractive applications in one-pot multi-step transformations catalysed by palladium, such as C-C coupling followed by hydrogenation, without isolation of intermediates using only one catalytic precursor. Copyright