238742-80-8

Basic information

• Product Name: 3-FLUORO-4-METHYLBENZAMIDE OXIME
• Synonyms: 3-FLUORO-N'-HYDROXY-4-METHYLBENZENECARBOXIMIDAMIDE;3-FLUORO-4-METHYLBENZAMIDE OXIME;Benzenecarboximidamide,3-fluoro-N-hydroxy-4-methyl-;Benzenecarboximidamide, 3-fluoro-N-hydroxy-4-methyl- (9CI);3-Fluoro-N'-hydroxy-4-methylbenzenecarboximidamide, 95+%;(Z)-3-fluoro-N'-hydroxy-4-MethylbenziMidaMide;3-Fluoro-N-hydroxy-4-methylbenzamidine
• CAS NO: 238742-80-8
• Molecular Formula: C₈H₉FN₂O
• Molecular Weight: 168.17
• Product Categories: AMIDINE
• Mol File: 238742-80-8.mol
• Article Data: 5

Chemical Properties

• Melting Point: 105-107°C
• Boiling Point: 317.6°Cat760mmHg
• Flash Point: 145.9°C
• Appearance: /
• Density: 1.25g/cm³
• PKA: 6.66±0.69(Predicted)
• CAS DataBase Reference: 3-FLUORO-4-METHYLBENZAMIDE OXIME(CAS DataBase Reference)
• NIST Chemistry Reference: 3-FLUORO-4-METHYLBENZAMIDE OXIME(238742-80-8)
• EPA Substance Registry System: 3-FLUORO-4-METHYLBENZAMIDE OXIME(238742-80-8)

Safety Data

• Hazard Codes: Xi,C
• Statements: 36/37/38-34
• Safety Statements: 26-36/37/39-45
• Hazardous Substances Data: 238742-80-8(Hazardous Substances Data)

Usage

General Description

3-Fluoro-4-methylbenzamide oxime is a chemical compound with the molecular formula C8H8FNO2. It is an oxime derivative of 3-fluoro-4-methylbenzamide, a white crystalline solid with a melting point of 128-130°C. 3-FLUORO-4-METHYLBENZAMIDE OXIME is used in organic and medicinal chemistry as a building block for various pharmaceuticals and agrochemicals. It also has potential applications in research and development of new drugs due to its unique structural and functional properties. Additionally, it can be used as a reagent in chemical synthesis and as a reference standard in analytical testing. Overall, 3-fluoro-4-methylbenzamide oxime has important industrial and scientific uses in the field of chemistry and pharmaceuticals.

Upstream product

• 5470-11-1 hydroxylamine hydrochloride 
• 170572-49-3 2-fluoro-4-cyanotoluene 

Downstream Products

• 1146699-63-9 3-(3-fluoro-4-methylphenyl)-1,2,4-oxadiazole 

Relevant articles and documents

Design, Synthesis, and Pesticidal Activities of Pyrimidin-4-amine Derivatives Bearing a 5-(Trifluoromethyl)-1,2,4-oxadiazole Moiety

It is important to discover new pesticides with new modes of action because of the increasing evolution of pesticide resistance. In this study, a series of novel pyrimidin-4-amine derivatives containing a 5-(trifluoromethyl)-1,2,4-oxadiazole moiety were designed and synthesized. Their structures were confirmed by 1H NMR, 13C NMR, and HRMS. Bioassays indicated that the 29 compounds synthesized possessed excellent insecticidal activity against Mythimna separata, Aphis medicagini, and Tetranychus cinnabarinus and fungicidal activity against Pseudoperonospora cubensis. Among these pyrimidin-4-amine compounds, 5-chloro-N-(2-fluoro-4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzyl)-6-(1-fluoroethyl)pyrimidin-4-amine (U7) and 5-bromo-N-(2-fluoro-4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzyl)-6-(1-fluoroethyl) pyrimidin-4-amine(U8) had broad-spectrum insecticidal and fungicidal activity. The LC50 values were 3.57 ± 0.42, 4.22 ± 0.47, and 3.14 ± 0.73 mg/L for U7, U8, and flufenerim against M. separata, respectively. The EC50 values were 24.94 ± 2.13, 30.79 ± 2.21, and 3.18 ± 0.21 mg/L for U7, U8, and azoxystrobin against P. cubensis, respectively. The AChE enzymatic activity testing revealed that the enzyme activities of compounds U7, U8, and flufenerim are 0.215, 0.184, and 0.184 U/mg prot, respectively. The molecular docking results of compounds U7, U8, and flufenerim with the AChE model demonstrated the opposite docking mode between compound U7 or U8 and positive control flufenerim in the active site of AChE. The structure-activity relationships are also discussed. This work provided excellent pesticide for further optimization. Density functional theory analysis can potentially be used to design more active compounds.

FUNGICIDAL COMPOSITIONS

A fungicidal composition comprising a mixture of components (A) and (B), wherein components (A) and (B) are as defined in claim 1, and use of the compositions in agriculture or horticulture for controlling or preventing infestation of plants by phytopatho

Novel Alpha-(N-Sulfonamido)Acetamide Compound as an Inhibitor of Beta Amyloid Peptide Production

The present invention provides a novel alpha-(N-sulfonamido)acetamide compound, its pharmaceutical composition, processes thereof and a method for the treatment of Alzheimer's disease and other conditions associated with β-amyloid peptide.