2394-16-3Relevant articles and documents
A simple and convenient synthesis of 2-methoxyestradiol from estrone
Prakasham,Shanker, Karuna,Negi, Arvind S.
, p. 467 - 470 (2012/05/19)
A simple and straightforward synthesis of 2-methoxyestradiol have been achieved in nine synthetic steps with 21% of overall yield. Being a convenient process, it can be upscaled to industrial process.
Combined epimerisation and acylation: Meerwein-ponndorf-verley-oppenauer catalysts in action
Klomp, Dirk,Djanashvili, Kristina,Svennum, Nina Cianfanelli,Chantapariyavat, Nuttanun,Wong, Chung-Sing,Vilela, Filipe,Maschmeyer, Thomas,Peters, Joop A.,Hanefeld, Ulf
, p. 483 - 489 (2007/10/03)
A practical racemisation-epimerisation method for chiral secondary alcohols has been developed. Meerwein-Ponndorf-Verley-Oppenauer catalysts such as neodymium(III) isopropoxide are able to racemise these alcohols with retention of other stereocentres in the molecule. This is particularly useful for the recycling of the undesired products of kinetic resolutions of alcohols. By combination of such a racemisation with an acylation using isopropenyl or ethoxyvinyl esters as acyl donors, a fast straightforward recycling of starting materials may be achieved. The combined epimerisation and acylation process is demonstrated for the steroid estradiol methyl ether.
REDUCTIVE DESULFONYLATION OF PHENYL SULFONES BY SAMARIUM(II) IODIDE-HEXAMETHYLPHOSPHORIC TRIAMIDE
Kuenzer, H.,Stahnke, M.,Sauer, G.,Wiechert, R.
, p. 1949 - 1952 (2007/10/02)
Samarium(II) iodide in tetrahydrofuran reductively desulfonylates phenyl sulfones in the presence of hexamethylphosphoric triamide.This transformation is illustrated here for ten substrates, which include secondary alicyclic, β-hydroxy, vicinal bis-, and α,β-unsaturated sulfones.
