2396-17-0

Basic information

• Product Name: Benzenamine, 4-[1,2,2,2-tetrafluoro-1-(trifluoromethyl)ethyl]-
• CAS NO: 2396-17-0
• Molecular Formula: C9H6F7N
• Molecular Weight: 261.142
• Mol File: 2396-17-0.mol
• Article Data: 13

Chemical Properties

• CAS DataBase Reference: Benzenamine, 4-[1,2,2,2-tetrafluoro-1-(trifluoromethyl)ethyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenamine, 4-[1,2,2,2-tetrafluoro-1-(trifluoromethyl)ethyl]-(2396-17-0)
• EPA Substance Registry System: Benzenamine, 4-[1,2,2,2-tetrafluoro-1-(trifluoromethyl)ethyl]-(2396-17-0)

Safety Data

• Hazardous Substances Data: 2396-17-0(Hazardous Substances Data)

Upstream product

• 722-92-9 2-(4-aminophenyl)-1,1,1,3,3,3-hexafluoro-2-propanol 
• 422-85-5 perfluoropropyl bromide 
• 62-53-3 aniline 
• 98-95-3 nitrobenzene 
• 677-69-0 perfluoroisopropyl iodide 

Downstream Products

• 1187887-49-5 N-(2-chlorobenzoyl)-N'-(4-heptafluoroisopropylphenyl)urea 
• 1187887-22-4 N-(2,6-difluorobenzoyl)-N'-(4-heptafluoroisopropylphenyl)urea 
• 1187887-46-2 N-benzoyl-N'-(4-heptafluoroisopropylphenyl)urea 
• 238098-31-2 2-chloro-4-heptafluoroisopropyl-aniline 
• 862132-89-6 N-(2,6-dibromo-4-heptafluoroisopropyl)phenyl-3-nitrobenzamide 
• 1207315-60-3 2-chloro-N-(2,6-diiodo-4-(perfluoropropan-2-yl)phenyl)-3-nitrobenzamide 
• 1192021-29-6 2-amino-4-(perfluoropropan-2-yl)phenol 

Relevant articles and documents

Polyfluoroalkyl-containing isoindolinone benzamide derivative, preparation method and application thereof

The invention provides a polyfluoroalkyl-containing isoindolinone benzamide derivative, which has the following general formula A-1 as shown in the specification, wherein substituent groups are shown as the specification. The polyfluoroalkyl-containing isoindolinone benzamide derivative provided by the invention is suitable for agricultural insecticide.

Discovery of tetrahydroquinolines and benzomorpholines as novel potent RORγt agonists

The retinoic acid receptor-related orphan receptor γt (RORγt) is an important nuclear receptor that regulates the differentiation of Th17 cells and production of interleukin 17(IL-17). RORγt agonists increase basal activity of RORγt and could provide a potential approach to cancer immunotherapy. Herein, hit compound 1 was identified as a weak RORγt agonist during in-house library screening. Changes in LHS core of 1 led to the identification of tetrahydroquinoline compound 6 as a partial RORγt agonist (max. act. = 39.3%). Detailed structure-activity relationship on substituent of the LHS core, amide linker and RHS arylsulfonyl moiety was explored and a novel series of tetrahydroquinolines and benzomorpholines was discovered as potent RORγt agonists. Tetrahydroquinoline compound 8g (EC50 = 8.9 ± 0.4 nM, max. act. = 104.5%) and benzomorpholine compound 9g (EC50 = 7.5 ± 0.6 nM, max. act. = 105.8%) were representative compounds with high RORγt agonistic activity in dual FRET assay, and they showed good activity in cell-based Gal4 reporter gene assay and Th17 cell differentiation assay (104.5% activation at 300 nM of 8g; 59.4% activation at 300 nM of 9g). The binding modes of 8g and 9g as well as the two RORγt inverse agonists accidentally discovered were also discussed.

Synthesis and fungicidal activities of perfluoropropan-2-yl-based novel quinoline derivatives

A series of novel perfluoropropan-2-yl-based quinoline derivatives was designed and synthesized utilizing tebufloquin as the lead compound. The structures of all the newly synthesized compounds were confirmed by spectroscopic data 1HNMR, MS and elemental analysis. The results of bioassay indicated that these compounds exhibited potent fungicidal activities against Erysiphe graminis. Especially, compound 8c displayed excellent activity with EC50 value at 1.48 mg / L, which was better than that of the commercialized fungicide-tebufloquin. The structure-activity relationship for these new compounds was also discussed.