24003-66-5

Basic information

• Product Name: N-(1-oxopentyl)-glycine
• Synonyms: N-(1-oxopentyl)-glycine;Valerylglycine;Valeroyl glycine;N-Valerylglycine;Glycine,N-(1-oxopentyl)-;2-(Pentanoylamino)acetic acid
• CAS NO: 24003-66-5
• Molecular Formula: C₇H₁₃NO₃
• Molecular Weight: 159.19
• Mol File: 24003-66-5.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 381.6 ºC at 760 mmHg
• Flash Point: 184.6 ºC
• Appearance: /
• Density: 1.1 g/cm³
• Vapor Pressure: 7.01E-07mmHg at 25°C
• Refractive Index: 1.46
• Storage Temp.: Refrigerator
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: 3.60±0.10(Predicted)
• CAS DataBase Reference: N-(1-oxopentyl)-glycine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(1-oxopentyl)-glycine(24003-66-5)
• EPA Substance Registry System: N-(1-oxopentyl)-glycine(24003-66-5)

Safety Data

• Hazardous Substances Data: 24003-66-5(Hazardous Substances Data)

Usage

Description

N-(1-oxopentyl)-glycine, also known as N-Pentanoylglycine, is an acyl derivative of Glycine (G615990). It is a compound that has a significant role in the medical field, particularly in the diagnosis of certain metabolic disorders.

Uses

Used in Medical Diagnostics:
N-(1-oxopentyl)-glycine is used as a diagnostic marker for inborn errors of metabolism, such as mitochondrial fatty acid β-oxidation defects. The presence of this compound, along with other metabolites, in urine can be detected and analyzed using liquid chromatography coupled with tandem mass spectrometry. This helps medical professionals identify and monitor the progression of these metabolic disorders, enabling timely intervention and treatment.

InChI:InChI=1/C7H13NO3/c1-2-3-4-6(9)8-5-7(10)11/h2-5H2,1H3,(H,8,9)(H,10,11)

Upstream product

• 638-29-9 n-valeryl chloride 
• 56-40-6 glycine 
• 109-52-4 valeric acid 

Relevant articles and documents

Repurposing the 3-Isocyanobutanoic Acid Adenylation Enzyme SfaB for Versatile Amidation and Thioesterification

Genome mining of microbial natural products enables chemists not only to discover the bioactive molecules with novel skeletons, but also to identify the enzymes that catalyze diverse chemical reactions. Exploring the substrate promiscuity and catalytic mechanism of those biosynthetic enzymes facilitates the development of potential biocatalysts. SfaB is an acyl adenylate-forming enzyme that adenylates a unique building block, 3-isocyanobutanoic acid, in the biosynthetic pathway of the diisonitrile natural product SF2768 produced by Streptomyces thioluteus, and this AMP-ligase was demonstrated to accept a broad range of short-chain fatty acids (SCFAs). Herein, we repurpose SfaB to catalyze amidation or thioesterification between those SCFAs and various amine or thiol nucleophiles, thereby providing an alternative enzymatic approach to prepare the corresponding amides and thioesters in vitro.

Derivatives of 2-aminoacetic acid

2-Pentanoylaminoacetic acid and pharmaceutically suitable salts thereof are claimed for use as pharmaceuticals. The compounds are useful in producing an effect on the central nervous system, especially in the treatment of various forms of epilepsy, of disninesiae, of parkinsonism, of memory troubles, of psychic troubles and of cerebral anoxia.

Formation of propionyl-, butyryl-, and other acylglycines by enzymes of Clostridium kluyveri.

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