24006-21-1

Basic information

• Product Name: N-methyl-N-(4-methylphenyl)hydrazine
• CAS NO: 24006-21-1
• Molecular Weight: 136.197
• Mol File: 24006-21-1.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: N-methyl-N-(4-methylphenyl)hydrazine(CAS DataBase Reference)
• NIST Chemistry Reference: N-methyl-N-(4-methylphenyl)hydrazine(24006-21-1)
• EPA Substance Registry System: N-methyl-N-(4-methylphenyl)hydrazine(24006-21-1)

Safety Data

• Hazardous Substances Data: 24006-21-1(Hazardous Substances Data)

Usage

General Description

N-methyl-N-(4-methylphenyl)hydrazine, also known as 4-MMPH, is a chemical compound with the molecular formula C9H14N2. It is a colorless to light yellow liquid that is used in research as a building block for the synthesis of other organic compounds. 4-MMPH is classified as a hydrazine derivative and is known to be a potential carcinogen. It has also been studied for its toxic effects on human health, particularly its potential to cause liver and kidney damage. Due to its hazardous nature, strict safety precautions should be taken when handling, storing, and using N-methyl-N-(4-methylphenyl)hydrazine.

Upstream product

• 937-24-6 N-methyl-N-nitroso-p-toluidine 
• 7440-66-6 zinc 
• 539-44-6 N-4-methylphenylhydrazine 
• 74-88-4 methyl iodide 
• 2028-84-4 p-methylbenzenediazonium chloride 
• 94542-53-7 10-p-Tolylazo-[9]anthrol 
• 623-08-5 N-methyl-p-toluidine 
• 60-29-7 diethyl ether 
• 7697-37-2 nitric acid 
• 7664-93-9 sulfuric acid 
• 136984-61-7 (E)-3-(p-tolylhydrazono)-2-butanone 

Downstream Products

• 100726-24-7 6-methyl-3-phenylbenzo[e][1,2,4]triazine 
• 36362-82-0 1,5-dimethyl-2,3-diphenyl-1H-indole 
• 947595-94-0 [Ti(NN(Me)(4-CH3C6H4))(4,4'-di-tert-butyl-2,2'-bipyridine)(N,N-di(pyrrolyl-α-methyl)-N-methylamine)] 
• 30724-66-4 N,N’-dimethyl-bis(4-methylphenyl)hydrazine 
• 74763-67-0 4-(N,N'-Dimethyl-N'-p-tolyl-hydrazino)-benzoic acid ethyl ester 
• 74763-68-1 diethyl 4,4′-(methylenebis(azanediyl))dibenzoate 
• 10541-82-9 ethyl 4-(methylamino)benzoate 
• 623-08-5 N-methyl-p-toluidine 
• 51596-02-2 C₂₀H₂₄N₂O₄ 
• 113407-58-2 1-(Methyl-p-tolyl-amino)-pyrrolidin-2-one 
• 26190-49-8 1,4-Bis-(p-methylphenyl)-1,4-dimethyl-2-tetrazen 
• 26190-53-4 1.4-Dimethyl-1-(4'-tolyl)-4-(p-carbaethoxyphenyl)-2-tetrazen 
• 26190-51-2 1.4-Dimethyl-1.4-bis(4-carbaethoxyphenyl)-2-tetrazen 
• 113407-50-4 4-Chloro-butyric acid N'-methyl-N'-p-tolyl-hydrazide 

Relevant articles and documents

Cobalt-Catalyzed, Directed Intermolecular C-H Bond Functionalization for Multiheteroatom Heterocycle Synthesis: The Case of Benzotriazine

Transition-metal-catalyzed, directed intermolecular C-H bond functionalization is synthetically useful but heavily underexplored in multiheteroatom heterocycle synthesis. Herein we report a cobalt catalytic method for the formation of a three-nitrogen-bearing benzotriazine scaffold via the coupling of arylhydrazine and oxadiazolone. This synthetic protocol features a low-cost base metal catalyst, a maximum number of heteroatoms built into a heterocycle, a distinct synthetic logic for benzotriazines, a superior step economy, and a broad substrate scope.

A Versatile, Traceless C-H Activation-Based Approach for the Synthesis of Heterocycles

A versatile, traceless C-H activation-based approach for the synthesis of diversified heterocycles is reported. Rh(III)-catalyzed, N-amino-directed C-H alkenylation generates either olefination products or indoles (in situ annulation) in an atom- and step-economic manner at room temperature. The remarkable reactivity endowed by this directing group enables scale-up of the reaction to a 10 g scale at a very low catalyst loading (0.01 mol %/0.1 mol %). Ex situ annulation of olefination product provides entry into an array of heterocycles.

AMIDE DERIVATIVES AND DRUGS

The present invention provides an amide derivative represented by the following formula [1]: wherein n represents 0 or 1; X represents CR4 or N; Y represents CR6 or N; Z represents CR7 or N; R1 and R2 may be the same or different and each represents hydrogen, optionally substituted alkyl, acyl, optionally substituted aryl, or an optionally substituted aromatic heterocyclic group; R4, R5, R6 and R7 may be the same or different and each represents hydrogen, halogen, hydroxy, amino, alkyl, haloalkyl, alkoxy, monoalkylamino, dialkylamino, arylalkyl, cyano, or nitro; and R3 represents optionally substituted alkylamino, optionally substituted arylamino, or optionally substituted cyclic amino, or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising them as an active ingredient. The compound of the present invention is useful as a TGF-β inhibitor.