240130-29-4

Basic information

• Product Name: N-[3-tert-butyl-5-(tert-butylamino-methyl)-4-hydroxy-phenyl]-acetamide
• CAS NO: 240130-29-4
• Molecular Weight: 292.422
• Mol File: 240130-29-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-[3-tert-butyl-5-(tert-butylamino-methyl)-4-hydroxy-phenyl]-acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[3-tert-butyl-5-(tert-butylamino-methyl)-4-hydroxy-phenyl]-acetamide(240130-29-4)
• EPA Substance Registry System: N-[3-tert-butyl-5-(tert-butylamino-methyl)-4-hydroxy-phenyl]-acetamide(240130-29-4)

Safety Data

• Hazardous Substances Data: 240130-29-4(Hazardous Substances Data)

Upstream product

• 50-00-0 formaldehyd 
• 4151-47-7 N-<3-(1,1-dimethylethyl)-4-hydroxyphenyl>acetamide 
• 75-64-9 tert-butylamine 

Relevant articles and documents

New 4-aminoquinoline Mannich base antimalarials. 1. Effect of an alkyl substituent in the 5'-position of the 4'-hydroxyanilino side chain

A new series of 4-aminoquinoline Mannich base derivatives have been synthesized, in which the 3'-diethylamino function of amodiaquine (AQ) is replaced by a 3'-tert-butylamino group and an aliphatic hydrocarbon entity is incorporated into the 5'-position of the 4'-hydroxyanilino side chain. Seven alkyl Mannich base derivatives were screened and found to be active against both chloroquine-sensitive and -resistant strains of Plasmodium falciparum in vitro. The propyl and isopropyl alkyl derivatives were found to be the most active; consequently these derivatives were tested against a nonsensitive strain of Plasmodium berghi in vivo and found to be 3-fold more active than AQ, irrespective of the route of administration (oral or intraperitoneal).