24015-80-3Relevant articles and documents
Four-Selective Pyridine Alkylation via Wittig Olefination of Dearomatized Pyridylphosphonium Ylides
Dolewski, Ryan D.,Fricke, Patrick J.,McNally, Andrew
supporting information, p. 21283 - 21288 (2021/08/25)
Methods to synthesize alkylated pyridines are valuable because these structures are prevalent in pharmaceuticals and agrochemicals. We have developed a distinct approach to construct 4-alkylpyridines using dearomatized pyridylphosphonium ylide intermediates in a Wittig olefination-rearomatization sequence. Pyridine N-activation is key to this strategy, and N-triazinylpyridinium salts enable coupling between a wide variety of substituted pyridines and aldehydes. The alkylation protocol is viable for late-stage functionalization, including methylation of pyridine-containing drugs. This approach represents an alternative to metal-catalyzed sp2-sp3 cross-coupling reactions and Minisci-type processes.
Substituted tetrahydropyridine derivatives acting on 5-HT receptors
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, (2008/06/13)
PCT No. PCT/GB96/02763 Sec. 371 Date Apr. 29, 1998 Sec. 102(e) Date Apr. 29, 1998 PCT Filed Nov. 13, 1996 PCT Pub. No. WO97/18204 PCT Pub. Date May 22, 1997Compounds having formula I, or salts or prodrugs thereof: are selective agonists of the 5-HT1D alpha receptor and are useful in the treatment of migraine and associated conditions.
A facile synthesis of functionalized 4-benzylpyridines by using mixed copper, zinc benzylic organometallics
Chia,Shiao
, p. 2033 - 2034 (2007/10/02)
A general approach by use of highly functionalized mixed copper zinc, benzylic organometallics to react with N-ethoxycarbonylpyridinium chloride to give regioselectively 4-benzylpyridines after oxygen oxidation in 30-75% yield is described.