240486-11-7

Basic information

• Product Name: 4-(2-bromophenylamino)-1-(phenylmethyl)-4-piperidinecarbonitrile
• Synonyms: 4-(2-bromophenylamino)-1-(phenylmethyl)-4-piperidinecarbonitrile
• CAS NO: 240486-11-7
• Molecular Weight: 370.292
• Mol File: 240486-11-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-(2-bromophenylamino)-1-(phenylmethyl)-4-piperidinecarbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-bromophenylamino)-1-(phenylmethyl)-4-piperidinecarbonitrile(240486-11-7)
• EPA Substance Registry System: 4-(2-bromophenylamino)-1-(phenylmethyl)-4-piperidinecarbonitrile(240486-11-7)

Safety Data

• Hazardous Substances Data: 240486-11-7(Hazardous Substances Data)

Upstream product

• 3612-20-2 1-phenylmethyl-4-piperidone 
• 7677-24-9 trimethylsilyl cyanide 
• 615-36-1 2-bromoaniline 

Downstream Products

• 240486-17-3 1'-(phenylmethyl)spiro[2H-indole-2,4'-piperidine]-3(1H)-imine 
• 968-86-5 1-benzyl-4-(phenylamino)piperidine-4-carbonitrile 
• 240486-23-1 1'-(phenylmethyl)-spiro[2H-indole-2,4'-piperidin]-3(1H)-one 
• 240486-31-1 C₂₂H₂₄N₂O 

Relevant articles and documents

Discovery and structure-activity relationships of spiroindolines as novel inducers of oligodendrocyte progenitor cell differentiation

A novel series of spiroindoline derivatives was discovered for use as inducers of oligodendrocyte progenitor cell (OPC) differentiation, resulting from optimization of screening hit 1. Exploration of structure-activity relationships led to compound 18, which showed improved potency (rOPC EC50 = 0.0032 μM). Furthermore, oral administration of compound 18 significantly decreased clinical severity in an experimental autoimmune encephalomyelitis (EAE) model.