24057-28-1Relevant articles and documents
Efficient synthesis, X-ray diffraction study and antimicrobial activity of some novel thiazolidin-4-ones and perhydro-1,3-thiazin-4-ones
Gautam, Deepika,Gautam, Poonam,Chaudhary, Ram P.
, p. 43 - 47 (2013)
Condensations of thiosemicarbazones 1 derived from 1-tetralones with chloroacetic acid and 2-bromopropionic acid in the presence of N -methylpyridinium p -toluenesulfonate (an ionic liquid) yield the corresponding 2-substituted 4-thiazolidinones 2. The re
Method for preparing (S)-2-[3-(3-fluorobenzyl)-4-(3-fluorobenzyloxy)benzylamino]propionamide and salts thereof
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Paragraph 0072-0075, (2017/05/12)
The invention relates to a method for preparing (S)-2-[3-(3-fluorobenzyl)-4-(3-fluorobenzyloxy)benzylamino]propionamide and salts thereof. Salts of (S)-2-[3-(3-fluorobenzyl)-4-(3-fluorobenzyloxy)benzylamino]propionamide mean (S)-2-[3-(3-fluorobenzyl)-4-(3-fluorobenzyloxy)benzylamino]propionamide mesylates. The preparation method comprises the step of preparing the target product through synthesizing novel compounds, i.e., 2-(3-bromo-4((3-fluorobenzyl)oxy)phenyl)-1,3-dioxolane and 2-((3-fluorobenzyl)oxy)-5-formyl phenylboronic acid and belongs to bran-new preparation methods. The yield of the (S)-2-[3-(3-fluorobenzyl)-4-(3-fluorobenzyloxy)benzylamino]propionamide prepared by the preparation method is 49.57%, and the HPLC purity reaches 78.92%, and the yield of the salts of the prepared (S)-2-[3-(3-fluorobenzyl)-4-(3-fluorobenzyloxy)benzylamino]propionamide is 50.40%, and the HPLC purity reaches 96.35%, so that the yield and the HPLC purity are improved greatly compared with those in the prior art.
2-(3-bromine-4-(3-fluorobenzyloxy)phenyl)-1,3-dioxolame and preparation method thereof
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Paragraph 0069; 0070; 0071, (2017/08/29)
The invention relates to a new compound 2-(3-bromine-4-(3-fluorobenzyloxy) phenyl)-1,3-dioxolame and a preparation method thereof. The preparation method includes: respectively preparing 3-bromine-4-(3-fluorobenzyloxy) benzaldehyde and 4-methyl benzenesulfonic acid pyridinium first, and allowing the 3-bromine-4-(3-fluorobenzyloxy) benzaldehyde to have reaction with the 4-methyl benzenesulfonic acid pyridinium to generate the 2-(3-bromine-4-(3-fluorobenzyloxy) phenyl)-1,3-dioxolame. The 2-(3-bromine-4-(3-fluorobenzyloxy) phenyl)-1,3-dioxolame prepared by the method can be directly used for preparing 3-(3-fluorobenzyl)-4-(3-fluorobenzyloxy) benzaldehyde, the yield of the prepared 3-(3-fluorobenzyl)-4-(3-fluorobenzyloxy) benzaldehyde reaches up to 64.85%, and the purity, measured by high performance liquid chromatography, of the 3-(3-fluorobenzyl)-4-(3-fluorobenzyloxy) benzaldehyde reaches 98.92%.
Esterification catalysis by pyridinium p -toluenesulfonate revisited - Modification with a lipid chain for improved activities and selectivities
Wang, Wei,Liu, Huimin,Xu, Shaoyi,Gao, Yong
supporting information, p. 2906 - 2912 (2013/09/02)
The lipid analogs of pyridinium p-toluenesulfonate (PPTS) were examined for catalysis of the condensation of an equimolar mixture of carboxylic acids and alcohols under mild conditions without removal of water. Although PPTS is a poor catalyst, the introduction of a lipid chain and nitro group significantly improved the activity of PPTS and led to selectivity at suppressing the elimination side reactions of alcohols. 2-Oleamido-5-nitro-pyridinium p-toluenesulfonate (6) is a lead catalyst that promoted various esterification reactions with yields up to 99%.