24059-89-0Relevant articles and documents
Development of a scaleable synthesis of NDT 9533750, a key intermediate to a series of novel subtype preferring GABAA partial agonists
Xu, Yuelian,Han, Bingsong,Wang, Zhe-Qing,Shaw, Kenneth R.,Chenard, Bertrand L.,Maynard, George,Xie, Linghong
, p. 716 - 720 (2007)
A scaleable route to 6-chloro-4-[2-(3-fluoropyridin-2-yl)-imidazol-1- ylmethyl]-5-propyl-pyrimidine (NDT 9S33750), a key intermediate to a series of novel subtype preferring GABAA partial agonists, is described in which various scaleup issues were addressed to provide an efficient and robust route for the preparation of kilogram quantities of the compound.
RAD51 Inhibitors
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Paragraph 0454-0455, (2019/03/30)
This application is directed to inhibitors of RAD51 represented by the following structural formula, and methods for their use, such as to treat cancer, autoimmune diseases, immune deficiencies, or neurodegenerative diseases.
A Bifunctional Reagent Designed for the Mild, Nucleophilic Functionalization of Pyridines
Fier, Patrick S.
supporting information, p. 9499 - 9502 (2017/07/24)
Herein is reported the design and application of a reagent for the direct functionalization of pyridines. These reactions occur under mild conditions and exhibit broad functional group tolerance, enabling the late-stage functionalization of drug-like molecules. The reagent can be easily prepared on large scale from inexpensive reagents, and reacts in the title reaction with acetonitrile, sodium chloride, and sodium methanesulfonate as the sole byproducts. Although this Communication focuses primarily on reactions with cyanide as nucleophile, preliminary experiments with other nucleophiles foreshadow the broad reaching synthetic utility of this approach.
