24099-13-6

Basic information

• Product Name: Benzoic acid, 5-[[bis(phenylmethyl)amino]acetyl]-2-hydroxy-, methyl ester, hydrochloride
• CAS NO: 24099-13-6
• Molecular Formula: C24H23NO4.ClH
• Molecular Weight: 425.912
• Mol File: 24099-13-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 5-[[bis(phenylmethyl)amino]acetyl]-2-hydroxy-, methyl ester, hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 5-[[bis(phenylmethyl)amino]acetyl]-2-hydroxy-, methyl ester, hydrochloride(24099-13-6)
• EPA Substance Registry System: Benzoic acid, 5-[[bis(phenylmethyl)amino]acetyl]-2-hydroxy-, methyl ester, hydrochloride(24099-13-6)

Safety Data

• Hazardous Substances Data: 24099-13-6(Hazardous Substances Data)

Upstream product

• 50-78-2 aspirin 
• 13110-96-8 5-acetylsalicylic acid 
• 36256-45-8 3-carbomethoxy-4-hydroxy-α-bromoacetophenone 
• 103-49-1 dibenzylamine 
• 16475-90-4 estere metilico dell'acido 5-acetilsalicilico 

Downstream Products

• 24085-18-5 methyl 5-(2-amino-1-hydroxyethyl)-2-hydroxybenzoate hydrochloride 
• 727641-92-1 5-(2-Amino-1-hydroxyethyl)-salicylsaeure-methylester 
• 63416-60-4 5-[2-[[3-(4-Fluorophenyl)-1-methylpropyl]amino]-1-hydroxyethyl]-2-hydroxybenzoic acid, methyl ester, hydrochloride 

Relevant articles and documents

Synthesis and Structure-Activity Relationships among α-Adrenergic Receptor Agonists of the Phenylethanolamine Type

Nineteen arylethanolamine derivatives related to norepinephrine were prepared and tested for α-adrenergic stimulant activity.In one series the analogues possess a p-hydroxy function, while the meta position is substituted by methyl, ethyl, isopropyl, cyclohexyl, fluoro, chloro, iodo, carboxy, carbomethoxy, and methylsulfamido groups.The other series is meta hydroxylated with the para position substituted by the same groups.The influence of these groups upon the α-adrenergic activity is discussed, and the compounds are compared to octopamine, normetanephrine,norepinephrine, and norphenylephrine.It has been found that the introduction of an isopropyl, cyclohexyl, and fluoro group in the meta position of octopamine improves its affinity by three, five, and six times, respectively, whereas when these groups are introduced in the para position of norphenylephrine their effects are always detrimental.The most active compound, α-(aminomethyl)-(4-fluoro-3-hydroxyphenyl)methanol (44), has about one-hundreth the affinity and the same intrinsic activity as norepinephrine.