241499-47-8

Basic information

• Product Name: 4-(4-isopropoxy-phenylamino)-piperidine-1-carboxylic acid tert-butyl ester
• CAS NO: 241499-47-8
• Molecular Weight: 334.459
• Mol File: 241499-47-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-(4-isopropoxy-phenylamino)-piperidine-1-carboxylic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-isopropoxy-phenylamino)-piperidine-1-carboxylic acid tert-butyl ester(241499-47-8)
• EPA Substance Registry System: 4-(4-isopropoxy-phenylamino)-piperidine-1-carboxylic acid tert-butyl ester(241499-47-8)

Safety Data

• Hazardous Substances Data: 241499-47-8(Hazardous Substances Data)

Upstream product

• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 7664-66-6 4-(isopropoxy)aniline 

Downstream Products

• 241499-48-9 4-[(4-Isopropoxy-phenyl)-(3-methyl-but-2-enyl)-amino]-piperidine-1-carboxylic acid tert-butyl ester 
• 241499-49-0 (4-Isopropoxy-phenyl)-(3-methyl-but-2-enyl)-piperidin-4-yl-amine 

Relevant articles and documents

The discovery of [1-(4-Dimethylamino-benzyl)-piperidin-4-yl]-[4-(3,3-dimethylbutyl)-phenyl]-(3-methyl-but-2-enyl)-amine, an N-type Ca+2 channel blocker with oral activity for analgesia

Our drug discovery efforts for N-type calcium channel blockers in the 4-piperidinylaniline series led to the discovery of an orally active analgesic agent 26. 1-[4-Dimethylamino-benzyl)-piperidin-4-yl]-[4-(3,3-dimethyl-butyl)-phenyl]-(3-methyl-but-2-enyl)-amine (26) showed high affinity to functionally block N-type calcium channels (IC50=0.7 μM in the IMR32 assay) and exhibited high efficacy in the anti-writhing analgesia test with mice (ED50=12 mg/kg by po and 4 mg/kg by iv). In this report, the rationale for the design, synthesis, biological evaluation, and pharmacokinetics of this series of blockers is described. Copyright (C) 2000 Elsevier Science Ltd.