24166-13-0 Usage
Description
CLOXAZOLAM is a benzodiazepine derivative characterized by its anxiolytic, hypnotic, and antihypertensive properties. It is primarily used as an anti-anxiety drug and is metabolized into the active metabolite Delorezepam (D230675). Due to its potential for misuse and dependence, CLOXAZOLAM is classified as a controlled substance.
Uses
Used in Pharmaceutical Industry:
CLOXAZOLAM is used as an anxiolytic agent for the treatment of anxiety disorders. It helps in alleviating symptoms such as excessive worry, tension, and nervousness by modulating the neurotransmitter activity in the brain.
Used in Sleep Aid Applications:
CLOXAZOLAM is used as a hypnotic agent to treat insomnia and other sleep disorders. Its sedative effects promote relaxation and facilitate sleep onset, improving sleep quality and duration.
Used in Antihypertensive Applications:
CLOXAZOLAM is used as an antihypertensive agent to manage high blood pressure. It helps in reducing the stress response and lowering the heart rate, thereby contributing to the regulation of blood pressure.
Used in Controlled Substances Regulation:
As a controlled substance, CLOXAZOLAM is used in the regulation and monitoring of its distribution, prescription, and consumption. This classification aims to prevent misuse, dependence, and diversion of the drug for illicit purposes.
Originator
Sepazon,Sankyo,Japan,1974
Manufacturing Process
As described in US Patent 3,772,371: To a solution of 5.8 g of 5-chloro-2-
bromoacetylamino-o-chlorobenzophenone in 120 ml of ethanol were added
0.95 g of ethanolamine and 1.3 g of sodium acetate. The resulting mixture
was heated under reflux for 16 hours.
After completion of the reaction, the solvent was distilled off and the residue
was extracted with dichloromethane. The extract was washed with water,
dried over anhydrous sodium sulfate and the solvent was distilled off to give
3.25 g of the desired product melting at 202° to 204°C with decomposition.
Therapeutic Function
Tranquilizer
Check Digit Verification of cas no
The CAS Registry Mumber 24166-13-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,4,1,6 and 6 respectively; the second part has 2 digits, 1 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 24166-13:
(7*2)+(6*4)+(5*1)+(4*6)+(3*6)+(2*1)+(1*3)=90
90 % 10 = 0
So 24166-13-0 is a valid CAS Registry Number.
InChI:InChI=1/C17H14Cl2N2O2/c18-11-5-6-15-13(7-11)17(12-3-1-2-4-14(12)19)9-23-10-21(17)8-16(22)20-15/h1-7H,8-10H2,(H,20,22)
24166-13-0Relevant articles and documents
Kinetics and mechanism of the acid-base equilibrium of mexazolam and comparison with those of other commercial benzodiazepinooxazole drugs
Kuruno,Kamiya,Kuwayama,Jinno,Yashiro,Ikeda
, p. 3831 - 3837 (2007/10/02)
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Intermediates for tricyclic benzodiazepines
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, (2008/06/13)
Tricyclic benzodiazepine derivatives ("A") bearing a hydroxylower alkyl substituent in the 1-position and a heterocyclic ring joined between positions 4 and 5 of the benzodiazepine moiety are described. The heterocyclic ring will contain the nitrogen atom appearing at position 4 of the benzodiazepine ring as well as the hetero atom, which may be either oxygen or nitrogen, attached to the carbon atom at the 5-position of the benzodiazepine ring. "A" bearing an oxygen atom in the new heterocyclic ring may be formed from the corresponding 4,5-unsaturated benzodiazepines by treatment with an epoxide compound in the presence of an acid catalyst. "A" bearing either a nitrogen or an oxygen atom in the new heterocyclic ring may be prepared by cyclization of the corresponding open compound. "A" are useful as sedative, muscle relaxant and anti-convulsant agents.
This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.