24167-53-1

Basic information

• Product Name: 4-Iodo-N,N-dimethylbenzamide
• Synonyms: 4-Iodo-N,N-dimethylbenzamide;N,N-Dimethylcarbamoyl-4-iodobenzene;p-Iodo-N,N-dimethylbenzamide
• CAS NO: 24167-53-1
• Molecular Formula: C₉H₁₀INO
• Molecular Weight: 275.08627
• Mol File: 24167-53-1.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 339℃
• Flash Point: 159℃
• Appearance: /
• Density: 1.649
• Vapor Pressure: 9.54E-05mmHg at 25°C
• Refractive Index: 1.606
• Storage Temp.: 2-8°C
• PKA: -1.36±0.70(Predicted)
• CAS DataBase Reference: 4-Iodo-N,N-dimethylbenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Iodo-N,N-dimethylbenzamide(24167-53-1)
• EPA Substance Registry System: 4-Iodo-N,N-dimethylbenzamide(24167-53-1)

Safety Data

• Hazardous Substances Data: 24167-53-1(Hazardous Substances Data)

Usage

General Description

4-Iodo-N,N-dimethylbenzamide is a chemical compound with the molecular formula C10H12INO and a molecular weight of 279.11 g/mol. It is an iodo-substituted benzamide derivative, which is commonly used as an intermediate in the synthesis of pharmaceutical compounds and research chemicals. This chemical is a white to off-white solid at room temperature, and it is sparingly soluble in water but soluble in organic solvents such as dimethyl sulfoxide and methanol. 4-Iodo-N,N-dimethylbenzamide is primarily used in chemical research and development, particularly in the pharmaceutical industry, although it has potential applications in other fields such as agrochemicals and material science. Additionally, it is important to handle this compound with caution, as it may pose health and environmental risks if not properly managed.

InChI:InChI=1/C9H10INO/c1-11(2)9(12)7-3-5-8(10)6-4-7/h3-6H,1-2H3

Upstream product

• 1711-02-0 4-iodobenzoic acid chloride 
• 619-58-9 4-iodobenzoic acid 
• 506-59-2 N,N-dimethylammonium chloride 
• 51934-41-9 4-iodobenzoic acid ethyl ester 
• 124-40-3 dimethyl amine 
• 15164-44-0 p-(iodophenyl)carboxaldehyde 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 885024-39-5 2-[6-(4-dimethylcarbamoyl-phenyl)-7-oxo-3-trifluoromethyl-4,5,6,7-tetrahydro-pyrazolo[3,4-c]pyridin-1-yl]-5-methoxybenzoic acid 
• 99847-42-4 (4-chlorophenyl)(4-iodophenyl)methanone 
• 1380167-95-2 N,N-dimethyl-4-(phenylethynyl)benzamide 

Relevant articles and documents

Continuous Flow Acylation of (Hetero)aryllithiums with Polyfunctional N,N-Dimethylamides and Tetramethylurea in Toluene

The continuous flow reaction of various aryl or heteroaryl bromides in toluene in the presence of THF (1.0 equiv) with sec-BuLi (1.1 equiv) provided at 25 °C within 40 sec the corresponding aryllithiums which were acylated with various functionalized N,N-

Heme Protein Catalysts for Carbon-Silicon Bond Formation In Vitro and In Vivo

The present invention provides compositions and methods for catalyzing the formation of carbon-silicon bonds using heme proteins. In certain aspects, the present invention provides heme proteins, including variants and fragments thereof, that are capable of carrying out in vitro and in vivo carbene insertion reactions for the formation of carbon-silicon bonds. In other aspects, the present invention provides methods for producing an organosilicon product, the method comprising providing a silicon-containing reagent, a carbene precursor, and a heme protein; and combining the components under conditions sufficient to produce an organosilicon product. Host cells expressing the heme proteins are also provided by the present invention.

In situ protection and deprotection of amines for iron catalyzed oxidative amidation of aldehydes

An environmentally friendly synthetic route by the application of CO2 to synthesize amides via in situ protection and deprotection of amines for iron catalyzed oxidative amidation of aldehydes was developed. Various secondary and tertiary amides have been synthesized in moderate to good yields under mild and neutral reaction conditions. The use of amine hydrochloride salts and hence base for neutralization step is totally avoided in this protocol.