24169-02-6 Usage
Description
Econazole nitrate is the nitrate salt form of Econazole, an imidazole-class antifungal medication. It is a white crystalline powder that is primarily used for the treatment of various skin infections caused by fungi. Econazole nitrate works by inhibiting the biosynthesis of ergosterol, a key component of the fungal cell membrane, which disrupts the normal permeability of the fungal membrane and ultimately leads to the death of the fungi.
Uses
Used in Pharmaceutical Industry:
Econazole nitrate is used as an antifungal agent for the treatment of skin infections such as athlete's foot, tinea, pityriasis versicolor, ringworm, and jock itch. It is effective against fungi such as Trichophyton rubrum, Trichophyton tonsurans, and Microsporum audouini.
Used in Topical and Vaginal Preparations:
Econazole nitrate is used as an azole antifungal in topical and vaginal preparations to prevent the growth of dermatophytes, yeast, and mold, providing relief from fungal infections.
Used in Antifungal Applications:
Econazole nitrate is used as an antifungal agent that inhibits ergosterol synthesis, a crucial component for the growth and survival of fungi, thus effectively treating fungal infections.
References
http://www.rxlist.com/econazole-nitrate-cream-drug/clinical-pharmacology.htm
https://en.wikipedia.org/wiki/Econazole
http://www.pdr.net/drug-summary/Econazole-Nitrate-econazole-nitrate-731
Originator
Pevaryl,Cilag Chemie,France,1976
Manufacturing Process
A suspension of 10.3 parts of α-(2,4-dichlorophenyl)-imidazole-1-ethanol and
2.1 parts of sodium hydride in 50 parts of dry tetrahydrofuran is stirred andrefluxed for 2 hours. After this reaction-time, the evolution of hydrogen is
ceased. Then there are added successively 60 parts dimethylformamide and 8
parts of p-chlorobenzylchloride and stirring and refluxing is continued for
another two hours. The tetrahydrofuran is removed at atmospheric pressure.
The dimethylformamide solution is poured onto water. The product, 1-[2,4-
dichloro-β-(p-chlorobenzyloxy)phenethyl]imidazole, is extracted with benzene.
The extract is washed with water, dried, filtered and evaporated in vacuo.
From the residual oily free base, the nitrate salt is prepared in the usual
manner in 2-propanol by treatment with concentrated nitric acid, yielding,
after recrystallization of the crude solid salt from a mixture of 2-propanol,
methanol and diisopropylether, 1-[2,4-dichloro-β-(pchlorobenzyloxy)phenethyl]imidazole nitrate; MP 162°C.
Therapeutic Function
Antifungal
Air & Water Reactions
Insoluble in water.
Fire Hazard
Flash point data for Econazole nitrate are not available; however, Econazole nitrate is probably combustible.
Biochem/physiol Actions
Econazole interacts with 14-α demethylase, a cytochrome P-450 enzyme necessary to convert lanosterol to ergosterol. Inhibition of ergosterol results in increased cellular permeability causing leakage of cellular contents. Econazole may also inhibit endogenous respiration, interact with membrane phospholipids, inhibit the transformation of yeasts to mycelial forms, inhibit purine uptake, and impair triglyceride and phospholipid biosynthesis.
Check Digit Verification of cas no
The CAS Registry Mumber 24169-02-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,4,1,6 and 9 respectively; the second part has 2 digits, 0 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 24169-02:
(7*2)+(6*4)+(5*1)+(4*6)+(3*9)+(2*0)+(1*2)=96
96 % 10 = 6
So 24169-02-6 is a valid CAS Registry Number.
24169-02-6Relevant articles and documents
Methods and compositions for intravaginal contraception
-
, (2008/06/13)
A gel formulation, which is inherently spermicidal and which provides an efficient delivery system for spermicidal and other contraceptively effective compounds intravaginally is disclosed. Said formulation is useful in methods of intravaginal contraception.
