241819-52-3

Basic information

• Product Name: GAMMA-PHENYL-ALPHA-(TRIFLUOROMETHYL)-
• Synonyms: GAMMA-PHENYL-ALPHA-(TRIFLUOROMETHYL)-;GAMMA-PHENYL-ALPHA-(TRIFLUOROMETHYL)-GAM;γ-phenyl-α-(trifluoromethyl)-γ-butyrolactone,mixture of cis and trans;5-phenyl-3-(trifluoromethyl)oxolan-2-one
• CAS NO: 241819-52-3
• Molecular Formula: C11H9F3O2
• Molecular Weight: 230.1831696
• Mol File: 241819-52-3.mol
• Article Data: 1

Chemical Properties

• Melting Point: 61-64 °C(lit.)
• Boiling Point: 315.5±42.0 °C(Predicted)
• Appearance: /
• Density: 1.326±0.06 g/cm3(Predicted)
• CAS DataBase Reference: GAMMA-PHENYL-ALPHA-(TRIFLUOROMETHYL)-(CAS DataBase Reference)
• NIST Chemistry Reference: GAMMA-PHENYL-ALPHA-(TRIFLUOROMETHYL)-(241819-52-3)
• EPA Substance Registry System: GAMMA-PHENYL-ALPHA-(TRIFLUOROMETHYL)-(241819-52-3)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 241819-52-3(Hazardous Substances Data)

Usage

Description

GAMMA-PHENYL-ALPHA-(TRIFLUOROMETHYL)is a chemical compound characterized by the presence of a phenyl group attached to the gamma carbon and a trifluoromethyl group attached to the alpha carbon. This molecule is recognized for its strong electron-withdrawing properties due to the trifluoromethyl group, and its aromatic phenyl group contributes to its stability and reactivity. These unique structural features make GAMMA-PHENYL-ALPHA-(TRIFLUOROMETHYL)a versatile and valuable building block in various fields.

Uses

Used in Pharmaceutical Industry:
GAMMA-PHENYL-ALPHA-(TRIFLUOROMETHYL)is utilized as a key building block in organic synthesis for the development of pharmaceuticals. Its unique properties allow for the creation of new chemical entities that can address various medical needs.
Used in Agrochemical Industry:
In the agrochemical sector, GAMMA-PHENYL-ALPHA-(TRIFLUOROMETHYL)serves as an essential component in the synthesis of compounds used in crop protection and pest management, contributing to the development of innovative and effective products.
Used in Materials Science:
GAMMA-PHENYL-ALPHA-(TRIFLUOROMETHYL)is employed in the field of materials science for the production of advanced materials with specific properties. Its electron-withdrawing nature and aromatic stability make it suitable for creating materials with tailored characteristics for various applications.
Used in Chemical Engineering:
In chemical engineering, GAMMA-PHENYL-ALPHA-(TRIFLUOROMETHYL)is applied in the design and development of new chemical processes and reactions. Its reactivity and stability make it a valuable tool for enhancing the efficiency and selectivity of chemical transformations.

Relevant articles and documents

Fluorinated butanolides and butenolides - Part 9. Synthesis of 2-(trifluoromethyl)butan-4-olides by Wittig reaction using methyl 3,3,3-trifluoropyruvate

2-(Trifluoromethyl)butan-4-olides 13 and 14 were prepared by a three-step synthesis starting from a Wittig reagent and methyl 3,3,3-trifluoropyruvate (1) as a building block. The Wittig reaction of (2-oxoalkyl)triphenylphosphonium bromides with pyruvate 1 gave intermediate 4-oxobutenoates 8 and 9, which were stepwise selectively reduced with zinc borohydride firstly at the double bond and subsequently at the oxo group to afford unstable 4-hydroxy-2-trifluoromethylalkanoates 11 and 12, which cyclised spontaneously to the end butenolides 13 and 14.