24201-52-3

Basic information

• Product Name: Oxazole, 5-butoxy-4-methyl-
• CAS NO: 24201-52-3
• Molecular Formula: C8H13NO2
• Molecular Weight: 155.197
• Mol File: 24201-52-3.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: Oxazole, 5-butoxy-4-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Oxazole, 5-butoxy-4-methyl-(24201-52-3)
• EPA Substance Registry System: Oxazole, 5-butoxy-4-methyl-(24201-52-3)

Safety Data

• Hazardous Substances Data: 24201-52-3(Hazardous Substances Data)

Upstream product

• 774596-25-7 N-n-butoxyoxalylalanine n-butyl ester 
• 44924-99-4 DL-alanine butyl ester 
• 77287-34-4 formamide 
• 19255-82-4 1,1-dibutoxy-2-propanone 
• 1493793-58-0 C₁₃H₂₁NO₄ 
• 23429-13-2 5-butoxy-4-methyl-oxazole-2-carboxylic acid 
• 613-29-6 N-Dibutylaniline 
• 33140-30-6 2-isocyano-propionic acid butyl ester 
• 1860-26-0 tri-(2-ethyl-n-hexyl)amine 
• 86965-96-0 N-formylalanine butyl ester 

Downstream Products

• 58-56-0 pyridoxal hydrochloride 
• 5196-20-3 7-hydroxy-6-methyl-1,3-dihydrofuro<3,4-c>pyridin 

Relevant articles and documents

Synthesis of [13C3]-B6 vitamers labelled at three consecutive positions starting from [13C3]-propionic acid

[13C3]-labelled vitamers (PN, PL and PM) of the B6 group were prepared starting from [13C3]-propionic acid. [13C3]-PN was synthesized in ten linear steps with an overall yield of 17%. Hereby, higher alkyl homologues of involved esters showed a positive impact on the reaction outcome of the intermediates in the chosen synthetic route. Oxidation of [13C3]-PN to [13C3]-PL was undertaken using potassium permanganate and methylamine followed by acid hydrolysis of the imine derivative. [13C3]-PM could be prepared from the oxime derivative of [13C3]-PN by hydrogenation with palladium.

Synthesis of 4-methyl-5- [...] method

The invention discloses a method for synthesizing 4-methyl-5-alkoxyl oxazole, the method comprises a step b or a step a to the step b in a synthesis route, the synthesis route is shown as the follows, the step a is characterized in that 1,1-dialkoxy acetone is reacted to acetyl halides to generate 1-alcoxyl-1-halogenated acetone; the step b is characterized in that 1-alcoxyl-halogenated acetone is performed a cyclization reaction with methanamide to generate 4-methyl-5-alkoxyl oxazole; wherein the substituted group R is C2-C12 alkyl, and the substituted group X is a halogen element. The synthetic method has the advantages of simple operation, easy acquisition and small toxicity of raw material, high reaction yield and less pollution, and the industrial large production requirement can be satisfied.

Process for the preparation of substituted oxazoles

The present invention relates to a process for preparing 5-alkoxy-substituted oxazoles, in particular for preparing 4-methyl-5-alkoxy-substituted oxazoles and also a process for preparing pyridoxine derivatives.